Raj RPA, Nashwan AJ. Enhancing prognostic accuracy in predicting rectal neuroendocrine neoplasms. World J Gastroenterol 2024; 30(37): 4087-4089 [PMID: 39474400 DOI: 10.3748/wjg.v30.i37.4087]
Corresponding Author of This Article
Abdulqadir J Nashwan, MSc, PhD, Research Scientist, Department of Nursing & Midwifery Research, Hamad Medical Corporation, Rayyan Road, Doha 3050, Qatar. anashwan@hamad.qa
Research Domain of This Article
Genetics & Heredity
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 7, 2024; 30(37): 4087-4089 Published online Oct 7, 2024. doi: 10.3748/wjg.v30.i37.4087
Enhancing prognostic accuracy in predicting rectal neuroendocrine neoplasms
Renin Peter AA Raj, Abdulqadir J Nashwan
Renin Peter AA Raj, Department of Medicine, Aston Medical School, Birmingham B4 7ET, United Kingdom
Abdulqadir J Nashwan, Department of Nursing & Midwifery Research, Hamad Medical Corporation, Doha 3050, Qatar
Author contributions: Raj RPA, Nashwan AJ contributed to writing the draft and critically reviewing the literature.
Conflict-of-interest statement: All the authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Abdulqadir J Nashwan, MSc, PhD, Research Scientist, Department of Nursing & Midwifery Research, Hamad Medical Corporation, Rayyan Road, Doha 3050, Qatar. anashwan@hamad.qa
Received: August 4, 2024 Revised: August 19, 2024 Accepted: September 5, 2024 Published online: October 7, 2024 Processing time: 53 Days and 2.1 Hours
Abstract
The recently published retrospective study introduces the GATIS score, a new predictive model for rectal neuroendocrine neoplasms. By analyzing data from a large Chinese multicenter cohort, the study shows that the GATIS score, incorporating tumor grade, T stage, tumor size, age, and prognostic nutritional index, demonstrates superior predictive power for overall survival and progression-free survival compared to traditional World Health Organization grade and tumor, nodes and metastases staging systems. This editorial aims to discuss the importance of the GATIS score, its potential impact on clinical practice, and the strengths and limitations of the study. Finally, it explores the significance, methodology, and clinical implications of these findings.
Core Tip: The GATIS score, developed from a 12-year study of 1408 patients with rectal neuroendocrine neoplasms (R-NENs) across 17 major Chinese centers, predicts overall survival and progression-free survival more accurately than World Health Organization grade and tumor-node-metastasis staging. This score offers improved personalized patient management and treatment planning. However, the study includes limitations such as short follow-up durations and exclusion of molecular and genetic factors. Addressing these in future research could further enhance treatment strategies for R-NENs.
