Traditional Medicine
Copyright ©The Author(s) 1997. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 1997; 3(3): 180-181
Published online Sep 15, 1997. doi: 10.3748/wjg.v3.i3.180
Alterations of erythrocyte ATPase activity and oxygen consumption in patients with liver-blood deficiency syndrome
Lin-Jie Shi, Jun-Fan Liu, Zi-Qiang Zhang, Yi-Qin Lu, Yi-Gang Shu, Guo-Lin Chen, Zhi-Hua Xin, Jin-Yao Xu
Lin-Jie Shi, Zi-Qiang Zhang, Guo-Lin Chen, Zhi-Hua Xin, Institute of Integrated TCM and Western Medicine, Hunan Medical University, Changsha 410008, Hunan Province, China
Jun-Fan Liu, Yi-Qin Lu, Jin-Yao Xu, Department of Biochemistry and Institute of Blood Biochemistry
Yi-Gang Shu, Institute of Hematology, Xiang Ya Hospital
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No.39170881.
Correspondence to: Dr. Lin-Jie Shi, Associate Professor, Institute of Integrated TCM and Western Medicine, Hunan Medical University, Changsha 410008, Hunan Province, China
Telephone: +86-731-4440388-3805 Fax: +86-731-4440312
Received: December 13, 1996
Revised: February 6, 1997
Accepted: March 13, 1997
Published online: September 15, 1997
Abstract

AIM: To investigate the pathophysiology of erythrocyte energy metabolic changes of patients with the traditional Chinese Medicine (TCM) liver-blood deficiency syndrome (LBDS).

METHODS: Erythrocyte membrane ATPase activity and oxygen consumption rate (OCR) were determined in 66 patients with LBDS, including 35 patients with iron deficiency anemia and 31 patients with chronic aplastic anemia. Thirty healthy adults served as controls.

RESULTS: ATPase activity and OCR were decreased in patients with LBDS.

CONCLUSION: The decreased erythrocyte ATPase activity and OCR might cause the energy hypometabolism in LBDS patients.

Keywords: erythrocytes; Cell membrane; Oxygen consumption; Adenosine triphosphatase; Liver-blood deficiency syndrome; Iron-deficiency anemia; Aplastic anemia