Alterations of erythrocyte ATPase activity and oxygen consumption in patients with liver-blood deficiency syndrome

doi:10.3748/wjg.v3.i3.180

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Traditional Medicine

World J Gastroenterol. Sep 15, 1997; 3(3): 180-181
Published online Sep 15, 1997. doi: 10.3748/wjg.v3.i3.180

Alterations of erythrocyte ATPase activity and oxygen consumption in patients with liver-blood deficiency syndrome

Lin-Jie Shi, Jun-Fan Liu, Zi-Qiang Zhang, Yi-Qin Lu, Yi-Gang Shu, Guo-Lin Chen, Zhi-Hua Xin, Jin-Yao Xu

Lin-Jie Shi, Zi-Qiang Zhang, Guo-Lin Chen, Zhi-Hua Xin, Institute of Integrated TCM and Western Medicine, Hunan Medical University, Changsha 410008, Hunan Province, China

Jun-Fan Liu, Yi-Qin Lu, Jin-Yao Xu, Department of Biochemistry and Institute of Blood Biochemistry

Yi-Gang Shu, Institute of Hematology, Xiang Ya Hospital

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No.39170881.

Correspondence to: Dr. Lin-Jie Shi, Associate Professor, Institute of Integrated TCM and Western Medicine, Hunan Medical University, Changsha 410008, Hunan Province, China

Telephone: +86-731-4440388-3805 Fax: +86-731-4440312

Received: December 13, 1996
Revised: February 6, 1997
Accepted: March 13, 1997
Published online: September 15, 1997

Abstract

AIM: To investigate the pathophysiology of erythrocyte energy metabolic changes of patients with the traditional Chinese Medicine (TCM) liver-blood deficiency syndrome (LBDS).

METHODS: Erythrocyte membrane ATPase activity and oxygen consumption rate (OCR) were determined in 66 patients with LBDS, including 35 patients with iron deficiency anemia and 31 patients with chronic aplastic anemia. Thirty healthy adults served as controls.

RESULTS: ATPase activity and OCR were decreased in patients with LBDS.

CONCLUSION: The decreased erythrocyte ATPase activity and OCR might cause the energy hypometabolism in LBDS patients.

Keywords: erythrocytes; Cell membrane; Oxygen consumption; Adenosine triphosphatase; Liver-blood deficiency syndrome; Iron-deficiency anemia; Aplastic anemia