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World J Gastroenterol. Jun 28, 2023; 29(24): 3758-3769
Published online Jun 28, 2023. doi: 10.3748/wjg.v29.i24.3758
Current status and future perspectives for the treatment of resectable locally advanced esophagogastric junction cancer: A narrative review
Yoshiaki Shoji, Kazuo Koyanagi, Kohei Kanamori, Kohei Tajima, Mika Ogimi, Kentaro Yatabe, Miho Yamamoto, Akihito Kazuno, Kazuhito Nabeshima, Kenji Nakamura, Takayuki Nishi, Masaki Mori
Yoshiaki Shoji, Kazuo Koyanagi, Kohei Kanamori, Kohei Tajima, Mika Ogimi, Kentaro Yatabe, Miho Yamamoto, Akihito Kazuno, Kazuhito Nabeshima, Kenji Nakamura, Takayuki Nishi, Masaki Mori, Department of Gastroenterological Surgery, Tokai University School of Medicine, Isehara 259-1193, Japan
Author contributions: Shoji Y and Koyanagi K contributed to Conceptualization; Shoji Y contributed to writing and original draft preparation; Kanamori K, Tajima K, Ogimi M, Yatabe K, Yamamoto M, Kazuno A, Nabeshima K, Nakamura K and Nishi T contributed to investigation; Koyanagi K and Mori M contributed to supervision; All authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kazuo Koyanagi, FACS, MD, PhD, Chairman, Professor, Department of Gastroenterological Surgery, Tokai University School of Medicine, 143, Shimokasuya, Isehara 259-1193, Japan. kkoyanagi@tsc.u-tokai.ac.jp
Received: March 28, 2023
Peer-review started: March 28, 2023
First decision: May 12, 2023
Revised: May 21, 2023
Accepted: June 2, 2023
Article in press: June 2, 2023
Published online: June 28, 2023
Processing time: 92 Days and 3.6 Hours
Abstract

Incidence rates for esophagogastric junction cancer are rising rapidly worldwide possibly due to the economic development and demographic changes. Therefore, increased attention has been paid to the prevention, diagnosis, and the treatment of esophagogastric junction cancer. Although there are discrepancies in the treatment strategy between Asian and Western countries, surgery remains the mainstay of treatment for esophagogastric junction cancer. Recent developments of perioperative multidisciplinary treatment may lead to better therapeutic effect, higher complete resection rate, and better control of the residual diseases, thus result in prolonged prognosis. In this review, we will focus on the treatment of locally advanced resectable esophagogastric junction cancer, and discuss the current status and future perspectives of the perioperative treatment including chemotherapy, radiation therapy, and immunotherapy, as well as the surgical strategy. Better understanding of the latest treatment strategy and future overlook may enable to standardize and individualize the treatment for esophagogastric junction cancer, thus leading to better prognosis for those patients.

Keywords: Esophagogastric junction cancer; Perioperative therapy; Neoadjuvant therapy; Surgery; Multidisciplinary treatment

Core Tip: In recent years, increased attention has been paid to the prevention, diagnosis, and the treatment of esophagogastric junction cancer. Recent developments of perioperative multidisciplinary treatment led to increased patient outcomes. In this review, we will focus on the current status and future perspectives of the perioperative treatment including chemotherapy, radiation therapy, targeted therapy, and immunotherapy, as well as the surgical strategy for locally advanced esophagogastric adenocarcinoma. Better understanding of the latest treatment strategy and future overlook may lead to better prognosis for the patients.