Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2022; 28(30): 4231-4234
Published online Aug 14, 2022. doi: 10.3748/wjg.v28.i30.4231
Alcohol-related diseases and liver metastasis: Role of cell-free network communication
Manuel Muro, Aurelia Collados-Ros, Isabel Legaz
Manuel Muro, Immunology Service, Instituto Murciano de investigación biosanitaria (IMIB), Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Murcia 30120, Spain
Aurelia Collados-Ros, Isabel Legaz, Department of Legal and Forensic Medicine, Biomedical Research Institute (IMIB), Regional Campus of International Excellence “Campus Mare Nostrum”, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
Author contributions: Legaz I contrubited to conceptualization; Muro M, Collados-Ros A, and Legaz I contrubited to writing-original draft preparation; Muro M and Legaz I contrubited to writing-review and editing, writing-original draft preparation, supervision, and writing-review and editing; all authors read and approved the final manuscript, read and approved the final manuscript.
Conflict-of-interest statement: There are no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Isabel Legaz, PhD, Senior Lecturer, Department of Legal and Forensic Medicine, Biomedical Research Institute (IMIB), Regional Campus of International Excellence “Campus Mare Nostrum”, Faculty of Medicine, University of Murcia, Campus de Espinardo, Murcia 30100, Spain. isalegaz@um.es
Received: May 12, 2022
Peer-review started: May 12, 2022
First decision: May 28, 2022
Revised: May 31, 2022
Accepted: July 18, 2022
Article in press: July 18, 2022
Published online: August 14, 2022

Alcohol intake is a risk factor for cancer development and metastatic disease progression. Extracellular vesicle (EV)-mediated interorgan communication is assumed to be significant in boosting tumorigenic pathways and disease progression. Recent research indicates that exosomes have a variety of roles in the development of cancer during pathophysiological conditions. The involvement of EV signaling during cancer progression in the alcohol environment is unknown. Therefore, understanding communication networks and the role of EVs as biomarkers can contribute significantly to developing strategies to address the serious public health problems associated with alcohol consumption and cancer.

Keywords: Exosomes, Liver metastasis, Alcohol-associated liver disease, Cancer

Core Tip: In this letter to the editor, we discussed the reality that alcohol consumption is a risk factor that acts by itself to favor the appearance of the carcinogenic process and its harmful evolution towards metastatic pathology. One of the hypotheses that have been suggested as important in metastasis and communication between cells and/or organs is the traffic of extracellular vesicles/exosomes that can play or promote tumorigenesis locally and even at a distance from the primary tumor. Unraveling these communication mechanisms and therapeutic possibilities may lead to new ways to combat cancer’s worsening, as metastasis, in the future.