Zhan YT, Su HY, An W. Glycosyltransferases and non-alcoholic fatty liver disease. World J Gastroenterol 2016; 22(8): 2483-2493 [PMID: 26937136 DOI: 10.3748/wjg.v22.i8.2483]
Corresponding Author of This Article
Yu-Tao Zhan, MD, Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang, Dongcheng District, Beijing 100730, China. yutaozhan@263.net
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Feb 28, 2016; 22(8): 2483-2493 Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2483
Glycosyltransferases and non-alcoholic fatty liver disease
Yu-Tao Zhan, Hai-Ying Su, Wei An
Yu-Tao Zhan, Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Hai-Ying Su, Department of Obstetrics and Gynecology, Shandong Jining First People’s Hospital, Jining 272011, Shandong Province, China
Wei An, Department of Cell Biology, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, Beijing 100069, China
Author contributions: An W conceived the review and revised the paper; Zhan YT and Su HY wrote the paper; Zhan YT and Su HY contributed equally to this work; Zhan YT and An w are equally Corresponding author.
Supported by The National Natural Science Foundation of China No. 81041017; Beijing Municipal Natural Science Foundation, No. 7112032; Beijing Municipal Laboratory for Liver Protection and Regulation of Regeneration, and Scientific Research Common Program of Beijing Municipal Commission of Education No. KM201510025017.
Conflict-of-interest statement: None of the authors has any conflicts-of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yu-Tao Zhan, MD, Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang, Dongcheng District, Beijing 100730, China. yutaozhan@263.net
Telephone: +86-10-58268463 Fax: +86-10-58268473
Received: May 11, 2015 Peer-review started: May 12, 2015 First decision: September 11, 2015 Revised: October 22, 2015 Accepted: November 19, 2015 Article in press: November 19, 2015 Published online: February 28, 2016 Processing time: 290 Days and 3 Hours
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease and its incidence is increasing worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. Glycosyltransferases (GTs) are a diverse class of enzymes involved in catalyzing the transfer of one or multiple sugar residues to a wide range of acceptor molecules. GTs mediate a wide range of functions from structure and storage to signaling, and play a key role in many fundamental biological processes. Therefore, it is anticipated that GTs have a role in the pathogenesis of NAFLD. In this article, we present an overview of the basic information on NAFLD, particularly GTs and glycosylation modification of certain molecules and their association with NAFLD pathogenesis. In addition, the effects and mechanisms of some GTs in the development of NAFLD are summarized.
Core tip: Nonalcoholic fatty liver disease (NAFLD) is characterized by a very complicated process which is regulated by a number of protein molecules. Glycosylation, one of the most common post-translational modifications of proteins in eukaryotic cells, has been suggested to play an important role in the pathogenesis of NAFLD. As glycosylation is mainly mediated through glycosyltransferases (GTs), it seems reasonable to speculate that the GTs play an important role in the pathogenesis of NAFLD.
