Zhang YF, Deng HL, Fu J, Zhang Y, Wei JQ. Pancreatitis in hand-foot-and-mouth disease caused by enterovirus 71. World J Gastroenterol 2016; 22(6): 2149-2152 [PMID: 26877620 DOI: 10.3748/wjg.v22.i6.2149]
Corresponding Author of This Article
Dr. Hui-Ling Deng, Department Second of Infectious Diseases, Xi′an Children′s Hospital, 69 Xijuyuanxiang, Lianhu District, Xi′an 710003, Shaanxi Province, China. denghuiling70@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yu-Feng Zhang, Hui-Ling Deng, Jia Fu, Yu Zhang, Department Second of Infectious Diseases, Xi′an Children′s Hospital, Xi′an 710003, Shaanxi Province, China
Jian-Qiang Wei, Department of Radiology, Xi′an Children′s Hospital, Xi′an 710003, Shaanxi Province, China
Author contributions: Fu J and Zhang Y collected the patient’s clinical data; Wei JQ provided the CT image; Zhang YF and Deng HL analyzed the data and wrote the paper.
Institutional review board statement: This article was reviewed and approved by the Institutional Review Board of Xi′an Children′s Hospital with protocol number 2015-014.
Informed consent statement: We have requested waiver of informed consent from the legal guardian of the patient for this report.
Conflict-of-interest statement: The authors declare no conflict of interest related to this report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Hui-Ling Deng, Department Second of Infectious Diseases, Xi′an Children′s Hospital, 69 Xijuyuanxiang, Lianhu District, Xi′an 710003, Shaanxi Province, China. denghuiling70@126.com
Telephone: +86-29-87692204 Fax: +86-29-87692009
Received: October 15, 2015 Peer-review started: October 15, 2015 First decision: November 5, 2015 Revised: November 18, 2015 Accepted: December 8, 2015 Article in press: December 8, 2015 Published online: February 14, 2016 Processing time: 100 Days and 8.5 Hours
Abstract
Some viruses, including certain members of the enterovirus genus, have been reported to cause pancreatitis, especially Coxsackie virus. However, no case of human enterovirus 71 (EV71) associated with pancreatitis has been reported so far. We here report a case of EV71-induced hand-foot-and-mouth disease (HFMD) presenting with pancreatitis in a 2-year-old girl. This is the first report of a patient with acute pancreatitis in HFMD caused by EV71. We treated the patient conservatively with nasogastric suction, intravenous fluid and antivirals. The patient’s symptoms improved after 8 d, and recovered without complications. We conclude that EV71 can cause acute pancreatitis in HFMD, which should be considered in differential diagnosis, especially in cases of idiopathic pancreatitis.
Core tip: Acute pancreatitis associated with enterovirus 71 (EV71) infection is extremely rare. We here report a case of EV71-induced hand-foot-and-mouth disease (HFMD) presenting with pancreatitis in a 2-year-old girl. This is the first case report of acute pancreatitis associated with EV71 infection. EV71 can cause acute pancreatitis in HFMD, which should be considered in differential diagnosis, especially in cases of idiopathic pancreatitis.
