Sonomura T, Anami S, Takeuchi T, Nakai M, Sahara S, Tanihata H, Sakamoto K, Sato M. Reactive lymphoid hyperplasia of the liver: Perinodular enhancement on contrast-enhanced computed tomography and magnetic resonance imaging. World J Gastroenterol 2015; 21(21): 6759-6763 [PMID: 26074715 DOI: 10.3748/wjg.v21.i21.6759]
Corresponding Author of This Article
Tetsuo Sonomura, MD, PhD, Department of Radiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8510, Japan. sonomura@wakayama-med.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Tetsuo Sonomura, Shinpei Anami, Taizo Takeuchi, Motoki Nakai, Morio Sato, Department of Radiology, Wakayama Medical University, Wakayama 641-8510, Japan
Shinya Sahara, Hirohiko Tanihata, Department of Radiology, Kishiwada Tokushukai Hospital, Kishiwada-shi 596-8522, Japan
Kazuki Sakamoto, Department of Surgery, Kishiwada Tokushukai Hospital, Kishiwada-shi 596-8522, Japan
Author contributions: Sahara S and Tanihata H performed diagnostic imaging; Sakamoto K performed partial hepatectomy; Sonomura T, Anami S, Takeuchi T and Nakai M acquired the data and researched the literature; Sonomura T and Sato M drafted and edited the manuscript.
Ethics approval: The patient had a standard treatment that was approved ethically.
Informed consent: Informed consent was obtained in a routine manner.
Conflict-of-interest: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tetsuo Sonomura, MD, PhD, Department of Radiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8510, Japan. sonomura@wakayama-med.ac.jp
Telephone: +81-73-441-0605 Fax: +81-73-444-3110
Received: November 5, 2014 Peer-review started: November 9, 2014 First decision: November 26, 2014 Revised: December 10, 2014 Accepted: February 5, 2015 Article in press: February 5, 2015 Published online: June 7, 2015 Processing time: 217 Days and 21.6 Hours
Abstract
We report the case of a 69-year-old woman with reactive lymphoid hyperplasia (RLH) of the liver. She underwent partial hepatectomy under a preoperative diagnosis of hepatocellular carcinoma; however, histopathological analysis revealed RLH. The liver nodule showed the imaging feature of perinodular enhancement in the arterial dominant phase on contrast-enhanced computed tomography and magnetic resonance imaging, which could be a useful clue for identifying RLH in the liver. Histologically, the perinodular enhancement was compatible with prominent sinusoidal dilatation surrounding the liver nodule.
Core tip: It is difficult to differentiate between reactive lymphoid hyperplasia (RLH) of the liver and malignant liver tumors such as hepatocellular carcinoma and liver metastases. We observed a liver nodule with perinodular enhancement in the arterial dominant phase on contrast-enhanced computed tomography and magnetic resonance imaging. We consider that this imaging feature could be a useful clue for identifying RLH in the liver. Histological analysis revealed the liver nodule in our patient to be RLH, with prominent sinusoidal dilatation around the nodule. This dilatation is the cause of the perinodular enhancement, which is useful for the accurate diagnosis of RLH.
