Meta-Analysis
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2015; 21(12): 3694-3705
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3694
Association between cadherin-17 expression and pathological characteristics of gastric cancer: A meta-analysis
Zi-Wen Long, Meng-Long Zhou, Jing-Wei Fu, Xian-Qun Chu, Ya-Nong Wang
Zi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Zi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Jing-Wei Fu, Xian-Qun Chu, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Author contributions: Chu XQ and Wang YN conceived of and designed the experiments; Long ZW and Zhou ML performed the experiments; Long ZW and Fu JW analyzed the data; Zhou ML and Fu JW contributed materials and analysis tools; Long ZW wrote the manuscript; Chu XQ and Wang YN reviewed and modified the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ya-Nong Wang, Professor, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. wangyanong731@163.com
Telephone: +86-21-64175590-1208 Fax: +86-21-2164430130
Received: July 17, 2014
Peer-review started: July 18, 2014
First decision: August 15, 2014
Revised: September 3, 2014
Accepted: October 21, 2014
Article in press: October 21, 2014
Published online: March 28, 2015
Processing time: 256 Days and 4.2 Hours
Abstract

AIM: To construct a meta-analysis in order to examine the relationship between cadherin-17 (CDH17) and gastric cancer (GC).

METHODS: Related articles were selected by searching the following English or Chinese electronic databases: CINAHL, MEDLINE, Science Citation Index, the Chinese Journal Full-Text, and the Weipu Journal. Newcastle-Ottawa Scale (NOS) criteria were used to ensure consistency in reviewing and reporting results. Statistical analyses were conducted with Version 12.0 STATA statistical software.

RESULTS: Ultimately, 11 articles, with a total of 2,120 GC patients, were found to be eligible for study inclusion. In comparisons of GC patients by TNM stage (III-IV vs I-II: OR = 2.35, 95%CI: 1.15-4.825, P = 0.019), histologic grade (3-4 vs 1-2: OR = 3.48, 95%CI: 1.36-8.92, P = 0.009), invasion grade (T3-4 vs T1-2: OR = 2.86; 95%CI: 1.69-4.83; P = 0.000), and lymph node metastasis (positive vs negative: OR = 2.64; 95%CI: 1.33-5.27; P = 0.006), it was found that CDH17 showed more positive expressions in each of the more severe cases. Country-stratified analyses from all four experimental subgroups showed that high CDH17 expression levels may be related to GC among Chinese and Korean populations (all P < 0.05), with the exception of the invasion grade T3-4 vs T1-2 comparison, where the relation only held among the Chinese population (OR = 2.86, 95%CI: 1.69-4.83, P = 0.000).

CONCLUSION: Collectively, the data reflects the capacity of CDH17 in tumor proliferation and metastasis among GC patients.

Keywords: Cadherin 17; Protein expression; Gastric cancer; Meta-analysis

Core tip: This meta-analysis conducted in order to examine the relationship between cadherin-17 (CDH17) and gastric cancer (GC), with the data reflecting the capacity of CDH17 in tumor proliferation and metastasis in GC patients.