Published online Sep 15, 1996. doi: 10.3748/wjg.v2.iSuppl1.130
Revised: April 28, 1996
Accepted: July 17, 1996
Published online: September 15, 1996
AIM: To investigate relationship between gastric motility and serum gastrin (GAS), somatostatin (SS), epidermal growth factor (EGF), motilin (MOT) levels of peptic ulcer disease before and after treatment.
METHODS: 42 patients with peptic ulcer and 24 patients with chronic superficial gastritis were studied. All patients were diagnosed with endoscopy. Hp was determined by radioimmunoassay. Among them, 19 patients were examined by electrogastrography (EGG).
RESULTS: The healing rate of DU was 86.1% after 4 wk treatment, the eradication rate of Hp was 88.8%. The levels of GAS, SS, EGF and MOT before treatment were significantly different from those after treatment. MOT is parallel with motility in DU. Increase of high frequency wave and mixture wave indicated that motility of stomach was increased. After healed, some hormone levels reduced to normal, while MOT and motility still abnormal. This indicated further treatment or observation were necessary.
CONCLUSION: Pathology of DU was related to not only the abnormal secretion and regulation of gut hormones, but also abnormal gastric motility. Before healing of DU the levels of GAS and MOT were higher, while SS, EGF were lower than those after healing of DU.