Brief Article
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World J Gastroenterol. Feb 14, 2013; 19(6): 931-935
Published online Feb 14, 2013. doi: 10.3748/wjg.v19.i6.931
Quadruple therapy for eradication of Helicobacter pylori
Hai-Jun Ma, Jin-Liang Wang
Hai-Jun Ma, Jin-Liang Wang, Department of Gastroenterology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China
Author contributions: Ma HJ collected data on the subject and prepare the manuscript; Wang JL conceived and designed the topic, reviewed and analyzed the literature.
Correspondence to: Jin-Liang Wang, Professor, Department of Gastroenterology, the First Affiliated Hospital of Henan University of Science and Technology, No. 24 Jinghua Road, Luoyang 471003, Henan Province, China. wangjinliang3008@163.com
Telephone: +86-379-64830750 Fax: +86-379-64907159
Received: September 18, 2012
Revised: November 11, 2012
Accepted: December 22, 2012
Published online: February 14, 2013
Processing time: 152 Days and 18.2 Hours
Abstract

AIM: To investigate quadruple therapy with rabeprazole, amoxicillin, levofloxacin and furazolidone for the eradication of Helicobacter pylori (H. pylori) infection.

METHODS: A total of 147 patients were divided into the experimental treatment group (n = 78) and the standard triple treatment group (n = 69). The experimental treatment group received rabeprazole 20 mg, amoxicillin 1.0 g, levofloxacin 0.2 g and furazolidone 0.1 g, twice daily. The standard triple treatment group received omeprazole 20 mg, amoxicillin 1.0 g and clarithromycin 0.5 g, twice daily.

RESULTS: One month after treatment, the 13C urea breath test was carried out to detect H. pylori. The eradication rate using per-protocol analysis was 94.3% in the experimental treatment group and 73% in the standard triple treatment group (P < 0.05), and using intention to test analysis, these figures were 86% and 67% in the two groups, respectively. Side effects were observed in 34 patients, and included mild dizziness, nausea, diarrhea and increased bowel movement. Eleven of the 34 patients needed no treatment for their side effects.

CONCLUSION: Rabeprazole, amoxicillin, levofloxacin and furazolidone quadruple therapy is a safe method for the eradication of H. pylori with high efficacy and good tolerability.

Keywords: Rabeprazole; Amoxicillin; Levofloxacin; Furazolidone; Helicobacter pylori