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World J Gastroenterol. Feb 7, 2013; 19(5): 784-785
Published online Feb 7, 2013. doi: 10.3748/wjg.v19.i5.784
Published online Feb 7, 2013. doi: 10.3748/wjg.v19.i5.784
Severe gastrointestinal mucositis following high dose melphalan therapy for multiple myeloma
Sanjeev Kumar Sharma, Anil Handoo, Dharma Choudhary, Gaurav Dhamija, Nitin Gupta, Department of Hemato-oncology and Bone Marrow Transplant, BLK Superspeciality Hospital, New Delhi 110005, India
Author contributions: Sharma SK, Handoo A, Choudhary D, Dhamija G, Gupta N designed and wrote the paper.
Correspondence to: Sanjeev Kumar Sharma, MD, DM, Department of Hemato-oncology and Bone Marrow Transplant, BLK Superspeciality Hospital, Pusa Road, New Delhi 110005, India. sksanjeev13@yahoo.com
Telephone: +91-11-30653790 Fax: +91-11-30653016
Received: October 15, 2012
Revised: November 10, 2012
Accepted: December 15, 2012
Published online: February 7, 2013
Processing time: 113 Days and 16.4 Hours
Revised: November 10, 2012
Accepted: December 15, 2012
Published online: February 7, 2013
Processing time: 113 Days and 16.4 Hours
Abstract
Mucositis is a known complication following use of chemotherapy, but fatal mucositis is unusual and management of such cases may be challenging. Pathologically there is denudation of mucosa of gastrointestinal tract. Severe cases can develop ileus and even perforation of bowel wall. We report here a case of multiple myeloma who developed World Health Organization grade 4 gut mucositis following the use of high dose melphalan with the expulsion of “intestine-like” material.
Keywords: Gastrointestinal mucositis; Chemotherapy