Olmez OF, Cubukcu E, Bayram AS, Akcali U, Evrensel T, Gebitekin C. Clinical outcomes of lung metastasectomy in patients with colorectal cancer. World J Gastroenterol 2012; 18(7): 662-665 [PMID: 22363137 DOI: 10.3748/wjg.v18.i7.662]
Corresponding Author of This Article
Omer Fatih Olmez, MD, Department of Medical Oncology, Uludag University Medical School, Bursa 16059, Turkey. ofolmez@uludag.edu.tr
Article-Type of This Article
Brief Article
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World J Gastroenterol. Feb 21, 2012; 18(7): 662-665 Published online Feb 21, 2012. doi: 10.3748/wjg.v18.i7.662
Clinical outcomes of lung metastasectomy in patients with colorectal cancer
Omer Fatih Olmez, Erdem Cubukcu, Ahmet Sami Bayram, Unsal Akcali, Turkkan Evrensel, Cengiz Gebitekin
Omer Fatih Olmez, Erdem Cubukcu, Turkkan Evrensel, Department of Medical Oncology, Uludag University Medical School, Bursa 16059, Turkey
Ahmet Sami Bayram, Cengiz Gebitekin, Department of Thoracic Surgery, Uludag University Medical School, Bursa 16059, Turkey
Unsal Akcali, Department of Internal Medicine, Uludag University Medical School, Bursa 16059, Turkey
Author contributions: Olmez OF and Bayram AS designed the research; Olmez OF, Cubukcu E, Bayram AS, and Akcali U performed the research; Evrensel T and Gebitekin C contributed new reagents; Cubukcu E, Olmez OF, and Bayram AS analyzed the data; and Olmez OF and Cubukcu E wrote the paper.
Correspondence to: Omer Fatih Olmez, MD, Department of Medical Oncology, Uludag University Medical School, Bursa 16059, Turkey. ofolmez@uludag.edu.tr
Telephone: +90-224-2951356 Fax: +90-224-4428166
Received: May 20, 2011 Revised: July 14, 2011 Accepted: July 26, 2011 Published online: February 21, 2012
Abstract
AIM: To investigate prognostic factors of survival following curative, non-palliative surgical removal of lung metastases secondary to colorectal cancer (CRC).
METHODS: Between 1999 and 2009, a radical metastasectomy with curative intent was performed on lung metastases in 21 patients with CRC (15 male and 6 female; mean age: 57.4 ± 11.8 years; age range: 29-74 years) who had already undergone primary tumour resection.
RESULTS: The mean number of lung metastases ranged from one to five. The mean overall survival was 71 ± 35 mo (median: 25 mo). After adjusting for potential confounders, multivariable Cox regression analyses predicted only the number of lung metastases (1 vs≥ 2; hazard ratio: 7.60, 95% confidence interval: 1.18-17.2, P = 0.03) as an independent predictor of poor survival following lung resection for metastatic CRC.
CONCLUSION: Resection of lung metastases is a safe and effective treatment in selected CRC patients with single lung metastases.
