Gong Y, Yang YS, Zhang XM, Su M, Wang J, Han JD, Guo MZ. ABO blood type, diabetes and risk of gastrointestinal cancer in northern China. World J Gastroenterol 2012; 18(6): 563-569 [PMID: 22363124 DOI: 10.3748/wjg.v18.i6.563]
Corresponding Author of This Article
Ming-Zhou Guo, PhD, MD, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. mzguo1@gmail.com
Article-Type of This Article
Brief Article
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World J Gastroenterol. Feb 14, 2012; 18(6): 563-569 Published online Feb 14, 2012. doi: 10.3748/wjg.v18.i6.563
ABO blood type, diabetes and risk of gastrointestinal cancer in northern China
Yan Gong, Yun-Sheng Yang, Xiao-Mei Zhang, Ming Su, Jean Wang, Jin-Dong Han, Ming-Zhou Guo
Yan Gong, Yun-Sheng Yang, Xiao-Mei Zhang, Ming-Zhou Guo, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China
Ming Su, Jin-Dong Han, Chinese Academy of Sciences Key Laboratory of Molecular Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Jean Wang, Department of Medicine (Gastroenterology), Johns Hopkins University, Baltimore, MD 21287, United States
Author contributions: Gong Y and Yang YS contributed equally to this work; Yang YS, Guo MZ and Gong Y designed the study, Gong Y and Zhang XM collected and analyzed the data, Gong Y, Guo MZ, Wang J, Han JD and Su M drafted the manuscript.
Supported by The National Basic Research Program, 973 Program No. 2010CB912802 and No. 2006CB910700; the China National Science Foundation, No. 81071953, No. 30890033 and No. 30620120433; the Chinese Academy of Sciences No. KSCX1-YW-R-40; and the 44 Postdoctoral Fund of China, No. 20080441314
Correspondence to: Ming-Zhou Guo, PhD, MD, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. mzguo1@gmail.com
Telephone: +86-10-66937651 Fax: +86-10-68180325
Received: June 18, 2010 Revised: March 14, 2011 Accepted: March 21, 2011 Published online: February 14, 2012
Abstract
AIM: To explore the potential risk factors related to gastrointestinal cancer in northern China.
METHODS: A total of 3314 cases of gastrointestinal cancer (esophageal, gastric, pancreatic and biliary) and 2223 controls (including healthy individuals, glioma and thyroid cancer) were analyzed by case-control study. Multivariable logistic regression analysis was applied to evaluate the association between different cancers and hepatitis B surface antigen, sex, age, blood type, diabetes, or family history of cancer.
RESULTS: Type 2 diabetes was significantly associated with gastric, biliary and pancreatic cancer with an OR of 2.0-3.0. Blood type B was significantly associated with esophageal cancer [odd ratio (OR) = 1.53, 95% confidence interval (CI) = 1.10-2.14] and biliary cancer (OR = 1.49, 95% CI = 1.09-2.05). The prevalence of type 2 diabetes was significantly higher in gastric, biliary and pancreatic cancers compared with other groups, with ORs ranging between 2.0 and 3.0. Family history of cancer was strongly associated with gastrointestinal compared with other cancers.
CONCLUSION: Blood type B individuals are susceptible to esophageal and biliary cancer. Type 2 diabetes is significantly associated with gastric, biliary and especially pancreatic cancer.
