Kim HH, Kim YS, Kang YK, Moon JS. Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma. World J Gastroenterol 2012; 18(6): 557-562 [PMID: 22363123 DOI: 10.3748/wjg.v18.i6.557]
Corresponding Author of This Article
You Sun Kim, MD, Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, 85 2-Ga, Jeo-Dong, Jung-Gu, Seoul 100-032, South Korea. yousunk69@korea.com
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Brief Article
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World J Gastroenterol. Feb 14, 2012; 18(6): 557-562 Published online Feb 14, 2012. doi: 10.3748/wjg.v18.i6.557
Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma
Hyung Hun Kim, You Sun Kim, Yun Kyung Kang, Jeong Seop Moon
Hyung Hun Kim, You Sun Kim, Jeong Seop Moon, Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul 100-032, South Korea
Yun Kyung Kang, Department of Pathology, Seoul Paik Hospital, Inje University College of Medicine, Seoul 100-032, South Korea
Hyung Hun Kim, Department of Internal Medicine, Kosin University College of Medicine, Busan 602-702, South Korea
Author contributions: Kim HH performed data analysis and wrote this paper; Kim YS guided the conception and design of this paper and revising it critically for important intellectual content; Kang YK was responsible for leptin and PPARG immunohistochemical staining and performed the interpretation of data; Moon JS supported the acquisition of data.
Supported by Grant from Inje University College of Medicine (2010)
Correspondence to: You Sun Kim, MD, Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, 85 2-Ga, Jeo-Dong, Jung-Gu, Seoul 100-032, South Korea. yousunk69@korea.com
Telephone: +82-2-22700012 Fax: +82-2-22794021
Received: April 28, 2011 Revised: September 7, 2011 Accepted: September 14, 2011 Published online: February 14, 2012
Abstract
AIM: To investigate the expressions of leptin and peroxisome proliferator-activated receptor γ (PPARG) in relation to body mass index (BMI).
METHODS: We evaluated leptin and PPARG expression in 30 adenomas over 1 cm in size by immunohistochemical staining. In addition, clinicopathologic features including BMI were assessed.
RESULTS: PPARG and leptin expression showed a strong positive correlation (P = 0.035). The average BMI of the leptin-positive group was higher than that of the leptin-negative group (25.4 ± 3.4 kg/m2vs 22.6 ± 2.4 kg/m2, P = 0.018), and leptin expression was significantly correlated with high BMI (P = 0.024). Leptin expression was more frequently observed in intermediate/high grade dysplasia than in low grade dysplasia (P = 0.030). However, PPARG expression was not correlated with BMI and grade of dysplasia.
CONCLUSION: BMI has influenced on the leptin expression of colorectal adenoma. The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.
