Zhao JD, Geng PL, Li ZQ, Cui S, Zhao JH, Wang LJ, Li JZ, Ji FX, Li GY, Shen GS, Lin MZ, Shen CF, Cao CZ. Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities. World J Gastroenterol 2012; 18(47): 7093-7099 [PMID: 23323013 DOI: 10.3748/wjg.v18.i47.7093]
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World J Gastroenterol. Dec 21, 2012; 18(47): 7093-7099 Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7093
Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities
Jiu-Da Zhao, Pai-Li Geng, Zhan-Quan Li, Sen Cui, Jun-Hui Zhao, Li-Juan Wang, Jin-Zhang Li, Fa-Xiang Ji, Guo-Yuan Li, Guo-Shuang Shen, Ming-Zhe Lin, Cun-Fang Shen, Cheng-Zhu Cao
Jiu-Da Zhao, Zhan-Quan Li, Sen Cui, Jun-Hui Zhao, Li-Juan Wang, Jin-Zhang Li, Fa-Xiang Ji, Guo-Yuan Li, Guo-Shuang Shen, Ming-Zhe Lin, Cun-Fang Shen, Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China
Jiu-Da Zhao, Pai-Li Geng, Cheng-Zhu Cao, High Altitude Medical Research Center, Qinghai University, Xining 810000, Qinghai Province, China
Author contributions: Zhao JD, Geng PL, Li ZQ, Cui S and Cao CZ designed the research and analyzed the data; Zhao JD wrote the paper; Zhao JH, Wang LJ, Li JZ, Ji FX, Li GY, Shen GS, Lin MZ and Shen CF contributed substantially to conception and design of the research and to the acquisition of data.
Supported by Grants from the National Natural Science Foundation of China, No. 30860259; and the Youth Scientific Research Foundation of Qinghai University, No. 2008-QY-09
Correspondence to: Jiu-Da Zhao, MD, Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China. jiudazhao@126.com
Telephone: +86-971-6162732 Fax: +86-971-6155740
Received: September 20, 2012 Revised: October 29, 2012 Accepted: November 8, 2012 Published online: December 21, 2012
Abstract
AIM: To investigate the associations between interleukin (IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet, Hui and Han ethnicities.
METHODS: Genomic DNA was extracted from peripheral blood of 210, 205, and 202 healthy volunteers and from 155, 158, and 197 gastric cancer patients from the Tibet, Hui, and Han populations, respectively. Polymorphisms in IL-1B and IL-1RN were analyzed by denaturing high-performance liquid chromatography.
RESULTS: Carriers of the IL-1B-31 CC genotype had an increased risk of intestinal type gastric cancer [odds ratio (OR) = 2.17, P = 0.037] in the Tibet ethnicity. Carriers of the IL-1B 2/L genotype had an increased risk of both intestinal and diffuse types of gastric cancer (OR = 2.08, 2.31, P = 0.007, 0.016, respectively) in the Hui ethnicity. In the Han population, carriers of the IL-1B-31 CC, IL-1B-511CT, TT genotypes had increased risk of intestinal type gastric cancer (OR = 2.51, 2.74, 5.66, P = 0.005, 0.002, 0.000, respectively).
CONCLUSION: IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet, Hui, and Han ethnicities in the Qinghai area of China.
