Chen JB, Li JL, He LH, Liu WQ, Yao F, Zeng JY, Zhang Y, Xu KQ, Niu LZ, Zuo JS, Xu KC. Radical treatment of stage IV pancreatic cancer by the combination of cryosurgery and iodine-125 seed implantation. World J Gastroenterol 2012; 18(47): 7056-7062 [PMID: 23323008 DOI: 10.3748/wjg.v18.i47.7056]
Corresponding Author of This Article
Li-Zhi Niu, MD, Professor of Medicine, Cryosurgery Institute of Guangzhou Fuda Cancer Hospital, No. 91-93 Judezhong Road, Haizhu District, Guangzhou 510665, Guangdong Province, China. fudaclab@gmail.com
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ji-Bing Chen, Jia-Liang Li, Wei-Qun Liu, Fei Yao, Jian-Ying Zeng, Central Lab of Guangzhou Fuda Cancer Hospital, Guangzhou 510665, Guangdong Province, China
Li-Hua He, Yi Zhang, Medical Information Department of Guangzhou Fuda Cancer Hospital, Guangzhou 510665, Guangdong Province, China
Ke-Qiang Xu, Li-Zhi Niu, Jian-Sheng Zuo, Ke-Cheng Xu, Cryosurgery Institute of Guangzhou Fuda Cancer Hospital, Guangzhou 510665, Guangdong Province, China
Author contributions: Chen JB and Li JL contributed equally to this study and share first authorship; Chen JB, Li JL and Niu LZ conceived and designed the experiments; Niu LZ, Zuo JS, Xu KQ and Xu KC performed the experiments; Chen JB, Zeng JY, and Yao F analyzed the data; He LH, Zhang Y and Liu WQ performed follow-ups and settled the data; Chen JB and Li JL wrote the paper.
Supported by The Hai Zhu District Scientific and Technological Plan, No. 2010-Y-27; “Comprehensive Research of Pancreatic Cancer Cryotherapy”, Guangzhou, China
Correspondence to: Li-Zhi Niu, MD, Professor of Medicine, Cryosurgery Institute of Guangzhou Fuda Cancer Hospital, No. 91-93 Judezhong Road, Haizhu District, Guangzhou 510665, Guangdong Province, China. fudaclab@gmail.com
Telephone: +86-20-34471220 Fax: +86-20-34471371
Received: February 8, 2012 Revised: March 20, 2012 Accepted: April 9, 2012 Published online: December 21, 2012
Abstract
AIM: To investigate the therapeutic effect of radical treatment and palliative treatment in stage IV pancreatic cancer patients.
METHODS: 81 patients were enrolled in the study. Radical treatment was performed on 51 patients, while 30 patients were put under palliative treatment. The procedural safety and interval survival for stage IV pancreatic cancer (IS-IV) was assessed by almost 2.5 years of follow-ups. The IS-IV of patients under the two kinds of treatment, and the effects of treatment timing and frequency on IS-IV, were compared.
RESULTS: The IS-IV of patients who received radical treatment was significantly longer than those who received palliative treatment (P < 0.001). The IS-IV of patients who received delayed radical or palliative treatment was longer than those who received accordingly timely treatment (P = 0.0034 and 0.0415, respectively). Multiple treatments can play an important role in improving the IS-IV of patients who received radical treatment (P = 0.0389), but not for those who received palliative treatment (P = 0.99).
CONCLUSION: The effect of radical treatment was significantly more obvious than that of palliative treatment, and multiple radical treatments may contribute more to patients than a single radical treatment.
