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World J Gastroenterol. Dec 21, 2012; 18(47): 6908-6917
Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6908
How regenerative medicine and tissue engineering may complement the available armamentarium in gastroenterology?
Marco Carbone, Jan Lerut, James Neuberger
Marco Carbone, Liver Unit, Addenbrookes Hospital, Cambridge CB2 0QQ, United Kingdom
Jan Lerut, Starzl Abdominal Transplant Unit, University Hospitals St. Luc, Université Catholique de Louvain, B-1200 Bruxelles, Belgium
James Neuberger, Organ Donation and Transplantation, NHS Blood and Transplant, Fox Den Road, Bristol BS34 8RR, United Kingdom
Author contributions: Carbone M, Lerut J and Neuberger J participated in the writing of the paper.
Correspondence to: Jan Lerut, Professor, Starzl Abdominal Transplant Unit, University Hospitals St. Luc, Université Catholique de Louvain, B-1200 Bruxelles, Belgium. jan.lerut@uclouvain.be
Telephone: +32-2-7641401 Fax: +32-2-7649039
Received: April 19, 2012
Revised: September 10, 2012
Accepted: October 30, 2012
Published online: December 21, 2012
Abstract

The increasing shortage of donors and the adverse effects of immunosuppression have restricted the impact of solid organ transplantation. Despite the initial promising developments in xenotransplantation, roadblocks still need to be overcome and this form of organ support remains a long way from clinical practice. While hepatocyte transplantation may be effectively correct metabolic defects, it is far less effective in restoring liver function than liver transplantation. Tissue engineering, using extracellular matrix scaffolds with an intact but decellularized vascular network that is repopulated with autologous or allogeneic stem cells and/or adult cells, holds great promise for the treatment of failure of organs within gastrointestinal tract, such as end-stage liver disease, pancreatic insufficiency, bowel failure and type 1 diabetes. Particularly in the liver field, where there is a significant mortality of patients awaiting transplant, human bioengineering may offer a source of readily available organs for transplantation. The use of autologous cells will mitigate the need for long term immunosuppression thus removing a major hurdle in transplantation.

Keywords: Regenerative medicine; Tissue engineering; Organ transplantation; Cellular transplantation; Xenotransplantation