Brief Article
Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Mar 14, 2011; 17(10): 1362-1367
Published online Mar 14, 2011. doi: 10.3748/wjg.v17.i10.1362
Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer
Jie Liu, Bao Song, Jia-Lin Wang, Zeng-Jun Li, Wan-Hu Li, Zhe-Hai Wang
Jie Liu, Zeng-Jun Li, Zhe-Hai Wang, Department of Chemotherapy Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China
Bao Song, Jia-Lin Wang, Wan-Hu Li, Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China
Author contributions: Liu J and Song B contributed equally to this work; Liu J, Song B and Wang ZH designed the research; Liu J, Song B, Wang JL and Li ZJ performed the research; Song B and Li WH analyzed the data; Liu J, Song B and Wang ZH wrote the paper.
Supported by Natural Science Foundation of Shandong Province China, No. ZR2009CM138
Correspondence to: Zhe-Hai Wang, MD, Department of Chemotherapy Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China. wangzhehai64@126.com
Telephone: +86-531-67626332 Fax: +86-531-87984079
Received: August 20, 2010
Revised: November 24, 2010
Accepted: December 1, 2010
Published online: March 14, 2011
Abstract

AIM: To evaluate the association between of the interleukin-10 (IL-10) promoter polymorphisms and survival of advanced gastric cancer (GC) patients.

METHODS: The IL-10 (-1082, rs1800896; -819, rs1800871; and-592, rs1800896) genotypes in 234 patients with advanced gastric cancer and in 243 healthy controls were determined by polymerase chain reaction-restriction fragment length polymorphism assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional logistic regression for the associations between IL-10 genotypes and the risk of GC. The Kaplan-Meier method with log-rank testing was used to evaluate the association between genotype and survival of the patients.

RESULTS: The IL-10 -1082 G allele and GCC (-1082, -819 and -592) haplotype were associated with increased gastric cancer risks (OR 1.2, 95% CI 0.6-3.2, P = 0.007, for -1082 G allele, OR = 2.3, 95% CI, 1.2-4.1, P = 0.005, for GCC haplotype, respectively). However, none of the three IL-10 gene polymorphisms (-1082, -819 and -592) was correlated with gastric cancer survival (P > 0.05), and none of the genotypes of the three IL-10 sites was found as independent prognostic risk factors in the multivariate test.

CONCLUSION: IL-10 gene promoter polymorphisms may not be associated with the prognosis of advanced gastric cancer.

Keywords: Interleukin-10; Cytokine; Genetic polymorphism; Gastric cancer; Prognosis