Zhou YZ, Diao YT, Li H, Li HQ, Ma Q, Cui J. Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia. World J Gastroenterol 2010; 16(27): 3445-3449 [PMID: 20632450 DOI: 10.3748/wjg.v16.i27.3445]
Corresponding Author of This Article
Hui-Qing Li, Professor, Department of Epidemiology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877# Jingshi Road, Jinan 250062, Shandong Province, China. huiqing4192@yahoo.com.cn
Article-Type of This Article
Brief Article
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Ying-Zhi Zhou, School of Economics, Shandong University, 27# Shanda Nanlu, Jinan 250100, Shandong Province, China
Yu-Tao Diao, Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44# Wenhuaxi Road, Jinan 250012, Shandong Province, China
Hao Li, Tumor Center, Qilu Hospital of Shandong University, 107# Wenhuaxi Road, Jinan 250012, Shandong Province, China
Hui-Qing Li, Qing Ma, Jia Cui, Department of Epidemiology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877# Jingshi Road, Jinan 250062, Shandong Province, China
Author contributions: Zhou YZ, Diao YT and Li H performed the majority of experiments, they contributed equally to this work; Zhou YZ wrote the manuscript; Li HQ designed the study, analyzed the data and modified the manuscript; Ma Q and Cui J performed part of the experiments and were responsible for data collection and entry.
Supported by The Project of National Natural Science Foundation of China, No. 30571601; the 2004 Key Special Project of Scientific and Technological Development in Shandong Province, China, No. 2004GG1108039; and the 2007 Special Foundation for Postdoctoral Innovation Subject in Shandong Province of China, No. 200702034
Correspondence to: Hui-Qing Li, Professor, Department of Epidemiology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, 18877# Jingshi Road, Jinan 250062, Shandong Province, China. huiqing4192@yahoo.com.cn
Telephone: +86-531-82919945 Fax: +86-531-82919930
Received: October 18, 2009 Revised: December 30, 2009 Accepted: January 6, 2010 Published online: July 21, 2010
Abstract
AIM: To demonstrate the possible associations between genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) and esophageal squamous cell dysplasia (ESCD).
METHODS: All participants came from an area of high incidence of esophageal cancer and underwent an endoscopic staining examination; biopsies were taken from a non-staining area of the mucosa and diagnosed by histopathology. Based on the examinations, the subjects were divided into the control group with normal esophageal squamous epithelial cells and the ESCD group. ALDH2 genotypes of 396 cases were determined including 184 ESCD cases and 212 controls. The odds ratio (OR) and 95% confidence intervals (95% CI) were calculated by binary logistic regression models.
RESULTS: The distribution of ALDH2 genotypes showed significant differences between the two groups. The adjustment factors were gender and age in the logistic regression models. Compared with 2*2/2*2 genotype, 2*1/2*1 genotype was found to be a risk factor for ESCD, and the OR (95% CI) was 4.50 (2.21-9.19). There were significant correlations between ALDH2 genotypes and alcohol drinking/smoking/history of esophageal cancer.
CONCLUSION: The ALDH2 polymorphism is significantly associated with ESCD.
