Al-Moundhri MS, Al-Khanbashi M, Al-Kindi M, Al-Nabhani M, Burney IA, Al-Farsi A, Al-Bahrani B. Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk. World J Gastroenterol 2010; 16(27): 3432-3436 [PMID: 20632448 DOI: 10.3748/wjg.v16.i27.3432]
Corresponding Author of This Article
Dr. Mansour S Al-Moundhri, Associate Professor and Consulting Oncologist, Medical Oncology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Muscat 123, Sultanate of Oman. mansours@squ.edu.om
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World J Gastroenterol. Jul 21, 2010; 16(27): 3432-3436 Published online Jul 21, 2010. doi: 10.3748/wjg.v16.i27.3432
Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk
Mansour S Al-Moundhri, Manal Al-Khanbashi, Mohammed Al-Kindi, Maryam Al-Nabhani, Ikram A Burney, Abdulaziz Al-Farsi, Bassim Al-Bahrani
Mansour S Al-Moundhri, Ikram A Burney, Medical Oncology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Sultanate of Oman
Manal Al-Khanbashi, Maryam Al-Nabhani, Department of Clinical Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Sultanate of Oman
Mohammed Al-Kindi, Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Sultanate of Oman
Abdulaziz Al-Farsi, Bassim Al-Bahrani, National Oncology Center, Royal Hospital, Muscat 111, Sultanate of Oman
Author contributions: Al-Moundhri MS designed the research, analyzed the data and wrote the manuscript; Al-Khanbashi M, Al-Nabhani M and Al-Kindi M performed the technical analysis; Burney IA, Al-Farsi A and Al-Bahrani B contributed to recruitment of patients and reviewed the manuscript.
Correspondence to: Dr. Mansour S Al-Moundhri, Associate Professor and Consulting Oncologist, Medical Oncology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Muscat 123, Sultanate of Oman. mansours@squ.edu.om
Telephone: +968-99437301 Fax: +968-24415175
Received: March 24, 2010 Revised: April 24, 2010 Accepted: May 1, 2010 Published online: July 21, 2010
Abstract
AIM: To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition.
METHODS: We analyzed four CDH1 polymorphisms (+54 T>C, -160 C>A, -616 G>C, -3159 T>C) in an Omani population, by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.
RESULTS: CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). There was no significant association between the other polymorphisms and GC risk. The haplotype analysis of +54 T>C, -160 C>A, -616 G>C, -3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5 (95% CI: 0.7-3.5) and 1.5 (95% CI: 0.2-3.0), but did not reach statistical significance.
CONCLUSION: The current study suggests that the -160 AA genotype was associated with an increased risk of GC in Oman.
