Brief Article
Copyright ©2010 Baishideng. All rights reserved.
World J Gastroenterol. Jun 21, 2010; 16(23): 2949-2953
Published online Jun 21, 2010. doi: 10.3748/wjg.v16.i23.2949
CYP2E1 PstI/RsaI polymorphism and colorectal cancer risk: A meta-analysis
Guo-Wu Zhou, Jia Hu, Qiang Li
Guo-Wu Zhou, Qiang Li, Department of Respiration, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Jia Hu, Department of Oncology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Author contributions: Zhou GW and Hu J contributed equally to this work; Zhou GW and Hu J conducted literature search and meta-analysis independently; Li Q provided the idea of this study and revised the manuscript.
Correspondence to: Qiang Li, MD, Professor, Doctoral Advisor, Department of Respiration, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China. liqressh@yahoo.com.cn
Telephone: +86-21-81873231 Fax: +86-21-51190920
Received: February 10, 2010
Revised: March 10, 2010
Accepted: March 17, 2010
Published online: June 21, 2010
Abstract

AIM: To clarify the association between CYP2E1 PstI/RsaI polymorphism and susceptibility to colorectal cancer.

METHODS: A meta-analysis based on 10 eligible case-control studies involving 4979 cases and 6012 controls was carried out to summarize the data on the association between CYP2E1 RsaI/PstI polymorphism and colorectal cancer risk.

RESULTS: In comparison of the homozygote c2c2 and c2 carriers (c1c2 + c2c2) and the homozygous wild-type genotype (c1c1), no association was found between CYP2E1 RsaI/PstI polymorphism and colorectal cancer risk [odds ratio (OR) = 1.24 (95% CI: 0.93-1.66) for c2c2; OR = 1.02 (95% CI: 0.88-1.19) for c2 carriers]. In stratified analysis, Caucasians with c2c2 homozygote appeared to have an increased risk of colorectal cancer (OR = 2.67, 95% CI: 1.03-6.89, P = 0.043), no significant associations were found in other groups.

CONCLUSION: c2c2 homozygote of CYP2E1 PstI/RsaI polymorphism may be associated with the increased risk of colorectal cancer in Caucasians, which needs further investigations.

Keywords: Cytochrome P450 2E1, PstI/RsaI polymorphism, Colorectal cancer, Cancer susceptibility, Meta-analysis