Brief Article
Copyright ©2010 Baishideng. All rights reserved.
World J Gastroenterol. May 21, 2010; 16(19): 2417-2420
Published online May 21, 2010. doi: 10.3748/wjg.v16.i19.2417
eGFR is a reliable preoperative renal function parameter in patients with gastric cancer
Takayuki Kosuge, Tokihiko Sawada, Yoshimi Iwasaki, Junji Kita, Mitsugi Shimoda, Nobumi Tagaya, Keiichi Kubota
Takayuki Kosuge, Tokihiko Sawada, Yoshimi Iwasaki, Junji Kita, Mitsugi Shimoda, Nobumi Tagaya, Keiichi Kubota, Second Department of Surgery, Dokkyo Medical University, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan
Author contributions: Kosuge T performed the whole study and wrote the manuscript; Sawada T designed and performed the study, and wrote the manuscript; Iwasaki Y, Kita J, Shimoda M and Tagaya N performed operations; Kubota K supervised the study and wrote the manuscript.
Correspondence to: Tokihiko Sawada, Associate Professor, Second Department of Surgery, Dokkyo Medical University, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan. tsawada@dokkyomed.ac.jp
Telephone: +81-282-861111 Fax: +81-282-866317
Received: October 13, 2009
Revised: December 11, 2009
Accepted: December 18, 2009
Published online: May 21, 2010
Abstract

AIM: To evaluate the validity of the estimated glomerular filtration rate (eGFR) as a preoperative renal function parameter in patients with gastric cancer.

METHODS: A retrospective study was conducted in 147 patients with gastric cancer. Preoperative creatinine clearance (Ccr), eGFR, and pre- and postoperative serum creatinine (sCr) data were examined. Preoperative Ccr and eGFR were then compared for their reliability in predicting postoperative renal dysfunction.

RESULTS: Among 110 patients with normal preoperative Ccr values, 7 (6.3%) had abnormal postoperative sCr values, and among 112 patients with normal preoperative eGFR values, postoperative sCr was abnormal in 5 (4.5%) (P = 0.53). Among 37 patients with abnormal preoperative Ccr values, 30 (81.1%) had normal postoperative sCr values, and of 35 patients with abnormal preoperative eGFR values, postoperative sCr was normal in 25 (71.4%) (P = 0.34). Preoperative Ccr was significantly correlated with eGFR (r = 0.514), and postoperative sCr was significantly correlated with preoperative Ccr (r = -0.334) and eGFR (r = -0.02).

CONCLUSION: Preoperative eGFR is as effective as Ccr for predicting postoperative renal dysfunction. eGFR should therefore be used as an indicator of preoperative renal function in place of Ccr since it is a cheaper and easier to perform test.

Keywords: Estimated glomerular filtration rate; Creatinine clearance test; Gastric cancer