Danese S, Fiorino G, Angelucci E, Vetrano S, Pagano N, Rando G, Spinelli A, Malesci A, Repici A. Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study. World J Gastroenterol 2010; 16(19): 2396-2400 [PMID: 20480525 DOI: 10.3748/wjg.v16.i19.2396]
Corresponding Author of This Article
Silvio Danese, MD, PhD, Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Viale Manzoni, Rozzano, Milan 20089, Italy. sdanese@hotmail.com
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Antonino Spinelli, Department of Surgery, IRCCS Istituto Clinico Humanitas, Rozzano, Milan 20089, Italy
Alberto Malesci, Department of Translational Medicine, University of Milan, Milan 20100, Italy
Author contributions: Danese S and Repici A designed the study; Danese S, Repici A and Angelucci E analyzed the data and wrote the manuscript; Fiorino G, Vetrano S, Pagano N, Rando G and Spinelli A acquired, analyzed and interpreted the data; Malesci A critically revised the manuscript.
Correspondence to: Silvio Danese, MD, PhD, Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Viale Manzoni, Rozzano, Milan 20089, Italy. sdanese@hotmail.com
Telephone: +39-2-82244771 Fax: +39-2-82245101
Received: September 17, 2009 Revised: November 5, 2009 Accepted: November 12, 2009 Published online: May 21, 2010
Abstract
AIM: To investigate whether narrow band imaging (NBI) is a useful tool for the in vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients.
METHODS: Conventional and NBI colonoscopy was performed in 14 patients with colonic inflammation (8 ulcerative colitis and 6 Crohn’s disease). Biopsy samples were taken and CD31 expression was assayed immunohistochemically; microvascular density was assessed by vessel count.
RESULTS: In areas that were endoscopically normal but positive on NBI, there was a significant (P < 0.05) increase in angiogenesis (12 ± 1 vessels/field vs 18 ± 2 vessels/field) compared with areas negative on NBI. In addition, in areas that were inflamed on white light endoscopy and positive on NBI, there was a significant (P < 0.01) increase in vessel density (24 ± 7 vessels/field) compared with NBI-negative areas.
CONCLUSION: NBI may allow in vivo imaging of intestinal angiogenesis in IBD patients.
