Doğan M, Peker E, Cagan E, Akbayram S, Acikgoz M, Caksen H, Uner A, Cesur Y. Stroke and dilated cardiomyopathy associated with celiac disease. World J Gastroenterol 2010; 16(18): 2302-2304 [PMID: 20458770 DOI: 10.3748/wjg.v16.i18.2302]
Corresponding Author of This Article
Murat Doğan, MD, Department of Pediatric Endocrinology, Yuzuncu Yil University, Medical School, 65100 Van, Turkey. doganmurat.md@gmail.com
Article-Type of This Article
Case Report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 14, 2010; 16(18): 2302-2304 Published online May 14, 2010. doi: 10.3748/wjg.v16.i18.2302
Stroke and dilated cardiomyopathy associated with celiac disease
Murat Doğan, Erdal Peker, Eren Cagan, Sinan Akbayram, Mehmet Acikgoz, Huseyin Caksen, Abdurrahman Uner, Yasar Cesur
Murat Doğan, Erdal Peker, Mehmet Acikgoz, Yasar Cesur, Department of Pediatric Endocrinology, Yuzuncu Yil University, Medical School, 65100 Van, Turkey
Eren Cagan, Huseyin Caksen, Department of Pediatric Neurology, Yuzuncu Yil University, Medical School, 65100 Van, Turkey
Sinan Akbayram, Department of Pediatric Hematology, Yuzuncu Yil University, Medical School, 65100 Van, Turkey
Abdurrahman Uner, Department of Pediatric Cardiology, Yuzuncu Yil University, Medical School, 65100 Van, Turkey
Author contributions: Doğan M was responsible for protocol development, patient screening, enrolment, outcome assessment, preliminary data analysis and writing the manuscript; Cesur Y, Uner A and Caksen H were responsible for patient screening, treatment and outcome assessment; Peker E, Cagan E, Akbayram S and Acikgoz M participated in the analytic framework for the study and contributed to the writing of the manuscript.
Correspondence to: Murat Doğan, MD, Department of Pediatric Endocrinology, Yuzuncu Yil University, Medical School, 65100 Van, Turkey. doganmurat.md@gmail.com
Telephone: +90-432-2158160 Fax: +90-432-21552814
Received: July 22, 2009 Revised: October 12, 2009 Accepted: October 19, 2009 Published online: May 14, 2010
Abstract
Celiac disease (CD) is manifested by a variety of clinical signs and symptoms that may begin either in childhood or adult life. Neurological symptoms without signs of malabsorption have been observed for a long time in CD. In this report, an 8-year-old girl with CD presented with rarely seen dilated cardiomyopathy and stroke. The girl was admitted with left side weakness. Her medical history indicated abdominal distention, chronic diarrhea, failure to thrive, and geophagia. On physical examination, short stature, pale skin and a grade 2 of 6 systolic murmur were detected. Muscle strength was 0/5 on the left side, and 5/5 on the right side. Coagulation examinations were normal. Tests for collagen tissue diseases were negative. Factor V Leiden and prothrombin GA20210 mutations were negative. Tandem mass spectrophotometry and blood carnitine profiles were normal. Brain magnetic resonance imaging and cerebral angiography showed an infarction area at the basal ganglia level. Examinations of serologic markers and intestinal biopsy revealed CD. We emphasize that in differential diagnosis of ischemic stroke, CD should be kept in mind.
