Brief Article
Copyright ©2010 Baishideng. All rights reserved.
World J Gastroenterol. Apr 28, 2010; 16(16): 2010-2016
Published online Apr 28, 2010. doi: 10.3748/wjg.v16.i16.2010
Change in renal function after sodium phosphate preparation for screening colonoscopy
Dong Choon Seol, Sung Noh Hong, Jeong Hwan Kim, In Kyung Sung, Hyung Seok Park, Jung Hyun Lee, Chan Sup Shim
Dong Choon Seol, In Kyung Sung, Hyung Seok Park, Jung Hyun Lee, Chan Sup Shim, Department of Internal Medicine, Konkuk University School of Medicine, Seoul 143-729, South Korea
Sung Noh Hong, Department of Health Promotion, Healthcare Center, Konkuk University Medical Center, Seoul 143-729, South Korea; Healthcare Center, Konkuk University Medical Center, Department of Internal Medicine, Konkuk University School of Medicine, Medical Immunology Center, Institute of Biomedical Science and Technology, Seoul 143-729, South Korea
Jeong Hwan Kim, Department of Internal Medicine, Konkuk University School of Medicine, Medical Immunology Center, Institute of Biomedical Science and Technology, Seoul 143-729, South Korea
Author contributions: Seol DC and Hong SN participated in data collection, designed the study, and wrote the manuscript; Kim JH, Sung IK, Park HS, Lee JH and Shim CS participated in data collection.
Supported by Konkuk University
Correspondence to: Sung Noh Hong, MD, Assistant Professor, Healthcare Center, Konkuk University Medical Center, Department of Internal Medicine, Konkuk University School of Medicine, Medical Immunology Center, Institute of Biomedical Science and Technology, 4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, South Korea. 20070253@kuh.ac.kr
Telephone: +82-2-20305010 Fax: +82-2-20307748
Received: January 14, 2010
Revised: February 3, 2010
Accepted: February 10, 2010
Published online: April 28, 2010
Abstract

AIM: To investigate the changes in renal function at 12-24 mo in patients following sodium phosphate (NaP) preparation for screening colonoscopy.

METHODS: We carried out a retrospective study on the results from patients who received health check-up services as part of an employer-provided wellness program performed between August 2006 and May 2008 and who were followed up for 12-24 mo. Prior to screening colonoscopy, 224 patients underwent bowel cleansing with NaP (NaP group) and 113 patients with polyethylene glycol (PEG group). The control group comprised 672 age-matched patients. We compared the changes in the creatinine levels and the glomerular filtration rates (GFRs) from baseline to 12-24 mo between the NaP, PEG, and control groups using two-way repeated measured analysis of variance. In addition, multivariate linear regression analysis was performed to assess the risk factors for a decreased GFR.

RESULTS: The baseline mean serum creatinine level in the NaP, PEG, and control groups was 1.12 ± 0.15, 1.12 ± 0.16, and 1.12 ± 0.15 mg/dL, which increased to 1.15 ± 0.15, 1.15 ± 0.18, and 1.15 ± 0.15 mg/dL, respectively, after 12-24 mo. The baseline mean GFR in the NaP, PEG, and control groups was 69.0 ± 7.7, 68.9 ± 8.0, and 69.6 ± 6.7 mL/min per 1.73 m2, which decreased to 66.5 ± 7.8, 66.5 ± 8.3, and 67.4 ± 6.4 mL/min per 1.73 m2, respectively, after 12-24 mo. The changes in serum creatinine levels and GFRs were not significantly between the NaP, PEG, and control groups (P = 0.992 and P = 0.233, respectively). Using multivariate linear regression analysis, only the baseline GFR was associated with the change in GFR (P < 0.001). Indeed, the bowel preparations were not associated with the change in GFR (P = 0.297).

CONCLUSION: NaP bowel preparation in subjects with normal renal function was not associated with renal injury, and NaP can thus be used safely for screening colonoscopy.

Keywords: Sodium phosphate; Polyethylene glycol; Purgatives; Colonoscopy; Creatinine; Glomerular filtration rate