Brief Article
Copyright ©2010 Baishideng. All rights reserved
World J Gastroenterol. Apr 21, 2010; 16(15): 1896-1900
Published online Apr 21, 2010. doi: 10.3748/wjg.v16.i15.1896
Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients
Kazuhisa Okada, Masahiko Inamori, Kento Imajyo, Hideyuki Chiba, Takashi Nonaka, Tadahiko Shiba, Takashi Sakaguchi, Kazuhiko Atsukawa, Hisao Takahashi, Etsuo Hoshino, Atsushi Nakajima
Kazuhisa Okada, Kento Imajyo, Hideyuki Chiba, Takashi Nonaka, Tadahiko Shiba, Takashi Sakaguchi, Kazuhiko Atsukawa, Hisao Takahashi, Department of Gastroenterology and Hepatology, Hiratsuka City Hospital, 1-19-1, Nanbara, Hiratsuka 254-0066, Japan
Masahiko Inamori, Atsushi Nakajima, Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
Etsuo Hoshino, Division of Endoscopy, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Japan, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan
Author contributions: Okada K, Inamori M, Imajyo K, Chiba H, Nonaka T and Nakajima A designed the research; Okada K, Inamori M, Shiba T, Sakaguchi T, Atsukawa K and Takahashi H performed the research; Okada K, Inamori M, Imajyo K, Chiba H and Sakaguchi T analyzed the data; Okada K, Inamori M, Hoshino E and Nakajima A wrote the paper.
Correspondence to: Masahiko Inamori, MD, PhD, Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. inamorim@med.yokohama-cu.ac.jp
Telephone: +81-45-7872640 Fax: +81-45-7843546
Received: November 3, 2009
Revised: December 18, 2009
Accepted: December 25, 2009
Published online: April 21, 2010
Abstract

AIM: To clarify the gender differences about the clinical features and risk factors of low-dose aspirin (LDA) (81-100 mg daily)-associated peptic ulcer in Japanese patients.

METHODS: There were 453 patients under treatment with LDA (298 males, 155 females) who underwent esophagogastroduodenoscopy at the Department of Gastroenterology and Hepatology of Hiratsuka City Hospital between January 2003 and December 2007. They had kept taking the LDA or started treatment during the study period and kept taking LDA during the whole period of observation. Of these, 119 patients (87 males, 32 females) were diagnosed as having LDA-associated peptic ulcer. We examined the clinical factors associated with LDA-associated peptic ulcer in both sexes.

RESULTS: A history of peptic ulcer was found to be the risk factor for LDA-associated peptic ulcer common to both sexes. In female patients, age greater than 70 years (prevalence ORs 8.441, 95% CI: 1.797-33.649, P = 0.0069) was found to be another significant risk factor, and the time to diagnosis as having LDA-associated peptic ulcer by endoscopy was significantly shorter than that in the male patients (P = 0.0050).

CONCLUSION: We demonstrated gender differences about the clinical features and risk factors of LDA-associated peptic ulcer. Special attention should be paid to aged female patients taking LDA.

Keywords: Low-dose aspirin; Gender; Peptic ulcer