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World J Gastroenterol. Mar 28, 2010; 16(12): 1553-1554
Published online Mar 28, 2010. doi: 10.3748/wjg.v16.i12.1553
Published online Mar 28, 2010. doi: 10.3748/wjg.v16.i12.1553
Gastric cardia adenocarcinoma in Taiwanese men: Positive associations due to selection bias
Diana Treviño Cervantes, Lori Ann Fischbach, Department of Epidemiology, School of Public Health, The University of North Texas Health Science Center, Fort Worth, TX 76104, United States
Author contributions: Cervantes DT contributed to the conception, writing and editing of the letter; Fischbach LA contributed to the writing and editing of the letter.
Correspondence to: Diana Treviño Cervantes, MS, MPH, Department of Epidemiology, School of Public Health, The University of North Texas Health Science Center, Fort Worth, TX 76104, United States. dcervantes@tarrantcounty.com
Telephone: +1-817-3215376 Fax: +1-817-3215353
Received: January 14, 2010
Revised: February 3, 2010
Accepted: February 10, 2010
Published online: March 28, 2010
Revised: February 3, 2010
Accepted: February 10, 2010
Published online: March 28, 2010
Abstract
The factors associated with an increase in gastric cardia adenocarcinoma are poorly understood. Environmental factors such as Helicobacter pylori (H. pylori) infection and diet have been hypothesized to play a role in the recently increased risk of this disease, but additional studies are needed. In conducting studies to establish the relationship between potential risk factors and gastric cardia adenocarcinoma, it is necessary to carefully consider the role of bias. In a recently published study, the reported associations between H. pylori as well as post-meal physical exertion and gastric cardia adenocarcinoma may have been greatly influenced by selection bias.