Hadithi M, Mulder CJ, Stam F, Azizi J, Crusius JBA, Peña AS, Stehouwer CD, Smulders YM. Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease. World J Gastroenterol 2009; 15(8): 955-960 [PMID: 19248194 DOI: 10.3748/wjg.15.955]
Corresponding Author of This Article
Dr. Muhammed Hadithi, Department of Gastroenterology, VUmc University Medical Center, PO Box 9119, 3007 AC Rotterdam, The Netherlands. hadithim@maasstadziekenhuis.nl
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World J Gastroenterol. Feb 28, 2009; 15(8): 955-960 Published online Feb 28, 2009. doi: 10.3748/wjg.15.955
Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease
Muhammed Hadithi, Chris JJ Mulder, Frank Stam, Joshan Azizi, J Bart A Crusius, Amado Salvador Peña, Coen DA Stehouwer, Yvo M Smulders
Muhammed Hadithi, Chris JJ Mulder, Joshan Azizi, Department of Gastroenterology, VUmc University Medical Center, Amsterdam, PO Box 7057, Amsterdam 1007 MB, The Netherlands
Frank Stam, Yvo M Smulders, Department of Internal Medicine, VUmc University Medical Center, Amsterdam, PO Box 7057, Amsterdam 1007 MB, The Netherlands
J Bart A Crusius, Amado Salvador Peña, Laboratory of Immunogenetics, Department of Pathology, VUmc University Medical Center, Amsterdam, PO Box 7057, Amsterdam 1007 MB, The Netherlands
Coen DA Stehouwer, Department of Internal Medicine, Academic Hospital Maastricht, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands
Author contributions: Hadithi M and Stehouwer CDA designed the study; Mulder CJJ coordinated and provided the inclusion of patients with celiac disease; Azizi J and Hadithi M set the data base and performed analysis; Crusius JBA and Peña AS coordinated and provided the analysis for the C677T polymorphism of 5, 10-methylenetetrahydrofolate reductase; Stam F and Smulders YM provided the healthy controls. All co-authors, especially Smulders YM, contributed in editing the manuscript.
Correspondence to: Dr. Muhammed Hadithi, Department of Gastroenterology, VUmc University Medical Center, PO Box 9119, 3007 AC Rotterdam, The Netherlands. hadithim@maasstadziekenhuis.nl
Telephone: +31-10-2911911
Fax: +31-10-2911911
Received: November 3, 2008 Revised: November 29, 2008 Accepted: December 6, 2008 Published online: February 28, 2009
Abstract
AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease.
METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals.
RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003), folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89).
CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management.
