Suzuki R, Irisawa A, Hikichi T, Takahashi Y, Kobayashi H, Kumakawa H, Ohira H. Cronkhite-Canada syndrome associated with myelodysplastic syndrome. World J Gastroenterol 2009; 15(46): 5871-5874 [PMID: 19998513 DOI: 10.3748/wjg.15.5871]
Corresponding Author of This Article
Rei Suzuki, MD, Department of Internal Medicine II, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan. enterotube@hotmail.com
Article-Type of This Article
Case Report
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World J Gastroenterol. Dec 14, 2009; 15(46): 5871-5874 Published online Dec 14, 2009. doi: 10.3748/wjg.15.5871
Cronkhite-Canada syndrome associated with myelodysplastic syndrome
Rei Suzuki, Atsushi Irisawa, Takuto Hikichi, Yuta Takahashi, Hiroko Kobayashi, Hiromi Kumakawa, Hiromasa Ohira
Rei Suzuki, Atsushi Irisawa, Takuto Hikichi, Hiroko Kobayashi, Hiromasa Ohira, Department of Internal Medicine II, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan
Yuta Takahashi, Hiromi Kumakawa, Internal Medicine, Soma Public Hospital, 142 Niinuma aza tubogasaku, Soma 976-0011, Japan
Author contributions: Suzuki R and Irisawa A wrote the paper; Suzuki R, Hikichi T, Takahashi Y, and Kumakawa H contributed to this work by direct participation in the work; Irisawa A, Kobayashi H and Ohira H designed, performed the work and revised it critically for important intellectual content.
Correspondence to: Rei Suzuki, MD, Department of Internal Medicine II, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan. enterotube@hotmail.com
Telephone: +81-24-5471202 Fax: +81-24-5472055
Received: September 21, 2009 Revised: October 20, 2009 Accepted: October 27, 2009 Published online: December 14, 2009
Abstract
We report a case of Cronkhite-Canada syndrome (CCS) associated with myelodysplastic syndrome (MDS). A 54-year-old woman, diagnosed as MDS the prior year after evaluation of anemia, visited our hospital with the chief complaint of epigastric discomfort. She also had dysgeusia, alopecia, atrophic nail change, and pigmentation of the palm, all of which began several months ago. Blood tests revealed severe hypoalbuminemia. Colonoscopy (CS) showed numerous, dense, red polyps throughout the colon and rectum. Biopsy specimens showed stromal edema, infiltration of lymphocytes, and cystic dilatation of the crypt. Her clinical manifestations and histology were consistent with CCS. We prescribed corticosteroids, which dramatically improved her physical findings, laboratory data, and endoscopic findings. This is the first report of CCS in a patient with MDS.
