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©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Dec 14, 2009; 15(46): 5776-5783
Published online Dec 14, 2009. doi: 10.3748/wjg.15.5776
Published online Dec 14, 2009. doi: 10.3748/wjg.15.5776
Signal molecule-mediated hepatic cell communication during liver regeneration
Zhen-Yu Zheng, Shun-Yan Weng, Yan Yu, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
Author contributions: Zheng ZY, Weng SY and Yu Y equally contributed to this paper.
Correspondence to: Yan Yu, PhD, School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Min Hang District, Shanghai 200240, China. yanyu@sjtu.edu.cn
Telephone: +86-21-34205833 Fax: +86-21-34205833
Received: September 5, 2009
Revised: October 14, 2009
Accepted: October 21, 2009
Published online: December 14, 2009
Revised: October 14, 2009
Accepted: October 21, 2009
Published online: December 14, 2009
Abstract
Liver regeneration is a complex and well-orchestrated process, during which hepatic cells are activated to produce large signal molecules in response to liver injury or mass reduction. These signal molecules, in turn, set up the connections and cross-talk among liver cells to promote hepatic recovery. In this review, we endeavor to summarize the network of signal molecules that mediates hepatic cell communication in the regulation of liver regeneration.
Keywords: Signal molecule; Hepatic cells; Cellular cross-talk; Signal communication; Liver regeneration