Li M, Gao X, Guo CC, Wu KC, Zhang X, Hu PJ. OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease. World J Gastroenterol 2008; 14(31): 4923-4927 [PMID: 18756601 DOI: 10.3748/wjg.14.4923]
Corresponding Author of This Article
Pin-Jin Hu, Professor, Department of Gastroenterology, the First Affiliated Hospital of Zhongshan University, Guangzhou 510089, Guangdong Province, China. pjhumd@vip.163.com
Article-Type of This Article
Rapid Communication
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World J Gastroenterol. Aug 21, 2008; 14(31): 4923-4927 Published online Aug 21, 2008. doi: 10.3748/wjg.14.4923
OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease
Mei Li, Xiang Gao, Chang-Cun Guo, Kai-Chun Wu, Xin Zhang, Pin-Jin Hu
Mei Li, Xiang Gao, Pin-Jin Hu, Department of Gastroenterology, the First Affiliated Hospital of Zhongshan University, Guangzhou 510089, Guangdong Province, China
Chang-Cun Guo, Kai-Chun Wu, Xin Zhang, Department of Gastroenterology, Xijing Hospital of the Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Author contributions: Gao X, Guo CC, Wu KC and Hu PJ designed the research; Li M and Zhang X performed the research; Li M analyzed data; and Li M wrote the paper.
Supported by Doctoral Natural Science Fund of Guangdong Province, China, No. 04300361
Correspondence to: Pin-Jin Hu, Professor, Department of Gastroenterology, the First Affiliated Hospital of Zhongshan University, Guangzhou 510089, Guangdong Province, China. pjhumd@vip.163.com
Telephone: +86-20-39745535 Fax: +86-20-87332741
Received: May 20, 2008 Revised: July 19, 2008 Accepted: July 26, 2008 Published online: August 21, 2008
Abstract
AIM: To investigate the single nucleotide polymorphism (SNPs) distribution of NOD2/CARD15 (R702W, G908R), OCTN1 1672C/T and OCTN2-207G/C in Chinese patients with inflammatory bowel disease (IBD).
METHODS: A total of 61 patients with Crohn’s disease (CD), 151 patients with ulcerative colitis (UC), and 200 unrelated healthy controls were genotyped. Genotyping was performed by sequence specific primer polymerase chain reaction (PCR-SSP) or by restriction fragment length polymorphism (PCR-RFLP) analysis.
RESULTS: Among the subjects in our study groups, including patients with CD, UC and healthy controls, none had OCTN and CARD15 variants and very rare IBD family history was found in our patients with the percentage of 0 (0/61 with CD) and 1.3% (2/151 with UC).
CONCLUSION: Our results indicate that although OCTN or CARD15 variation is associated with susceptibility to IBD in Western populations, these might be rare and may not be associated with susceptibility to IBD in Chinese patients.
