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World J Gastroenterol. Apr 21, 2008; 14(15): 2440-2447
Published online Apr 21, 2008. doi: 10.3748/wjg.14.2440
Analysis of risk factors for the interval time, number and pattern of hepatic metastases from gastric cancer after radical gastrectomy
Jing-Yu Deng, Han Liang, Dan Sun, Hong-Jie Zhan, Ru-Peng Zhang
Jing-Yu Deng, Han Liang, Hong-Jie Zhan, Ru-Peng Zhang, Gastrointestinal Cancer Department, Tianjin Cancer Hospital and City Key Laboratory of Cancer in Tianjin, Tianjin Medical University, Tianjin 300060, China
Dan Sun, Lung Cancer Research Institute, Tianjin General Hospital, Tianjin Medical University, Tianjin 300052, China
Author contributions: Deng JY and Liang H contributed equally to this work; Deng JY, and Liang H designed research; Deng JY, Liang H, Zhan HJ, and Zhang RP performed research; Sun D analyzed data; and Deng JY and Liang H wrote the paper.
Correspondence to: Jing-Yu Deng, Gastrointestinal Cancer Department, Tianjin Cancer Hospital and City Key Laboratory of Cancer in Tianjin, Tianjin Medical University, Tianjin 300060, China. dengery@126.com
Telephone: +86-22-23340123
Fax: +86-22-23359984
Received: January 15, 2008
Revised: March 6, 2008
Published online: April 21, 2008
Abstract

AIM: To analyze the risk factors for interval time, number and pattern of hepatic metastases from gastric cancer after radical gastrectomy, and provide evidence for predicting and preventing hepatic metastasis from gastric cancer after radical gastrectomy.

METHODS: A retrospective study of 87 patients with hepatic metastasis who underwent radical gastrectomy for gastric cancer from 1996 to 2001. The data was analyzed to evaluate significant risk factors for interval time, number and pattern of hepatic metastases originating from gastric cancer after radical gastrectomy.

RESULTS: The size of gastric cancer and lymph node metastases were independently correlated with the interval time of hepatic metastases; the depth of invasion was independently correlated with the number of hepatic metastases; while the depth of invasion and Lauren classification were independently correlated with the pattern of hepatic metastases.

CONCLUSION: We evaluated the interval time of hepatic metastases with the size of gastric cancer and lymph node metastases. The depth of invasion could be used to evaluate the number of hepatic metastases, while the depth of invasion and the Lauren classification could be used to evaluate the pattern of hepatic metastases in patients who underwent radical gastrectomy.

Keywords: Gastric cancer; Gastrectomy; Hepatic metastasis; Risk factor