Seo YS, Kim JN, Keum B, Park S, Kwon YD, Kim YS, Jeen YT, Chun HJ, Kim CY, Kim CD, Ryu HS, Um SH. Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma. World J Gastroenterol 2008; 14(15): 2394-2400 [PMID: 18416468 DOI: 10.3748/wjg.14.2394]
Corresponding Author of This Article
Soon Ho Um, Department of Internal Medicine, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Sungbuk-gu, Seoul 136-705, Korea. umsh@korea.ac.kr
Article-Type of This Article
Rapid Communication
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 21, 2008; 14(15): 2394-2400 Published online Apr 21, 2008. doi: 10.3748/wjg.14.2394
Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma
Yeon Seok Seo, Jin Nam Kim, Bora Keum, Sanghoon Park, Yong Dae Kwon, Yong Sik Kim, Yoon Tae Jeen, Hoon Jai Chun, Chul Yong Kim, Chang Duck Kim, Ho Sang Ryu, Soon Ho Um
Yeon Seok Seo, Jin Nam Kim, Bora Keum, Sanghoon Park, Yong Dae Kwon, Yong Sik Kim, Yoon Tae Jeen, Hoon Jai Chun, Chang Duck Kim, Ho Sang Ryu, Soon Ho Um, Department of Internal Medicine, Korea University College of Medicine, Seoul 136-705, Korea
Chul Yong Kim, Department of Radiation Oncology, Korea University College of Medicine, Seoul 136-705, Korea
Author contributions: Seo YS wrote the paper; Kim JN, Keum B, Park S, Kwon YD collected the data; Kim CY, Seo YS interpreted the treatment response; Kim YS, Jeen YT, Chun HJ, Kim CD, Ryu HS critically revised the paper; Um SH designed this study.
Correspondence to: Soon Ho Um, Department of Internal Medicine, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Sungbuk-gu, Seoul 136-705, Korea. umsh@korea.ac.kr
Telephone: +82-2-9206562
Fax: +82-2-9531943
Received: September 27, 2007 Revised: December 27, 2007 Published online: April 21, 2008
Abstract
AIM: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC).
METHODS: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage III and IV-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT.
RESULTS: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, α-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m≥ 20% than in those with TRR1m < 20% (P < 0.001).
CONCLUSION: RT is effective in treating advanced HCC with a tumor response rate of 56.9%.
