H pylori exist in the gallbladder mucosa of patients with chronic cholecystitis

doi:10.3748/wjg.v13.i10.1608

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2007; 13(10): 1608-1611
Published online Mar 14, 2007. doi: 10.3748/wjg.v13.i10.1608

H pylori exist in the gallbladder mucosa of patients with chronic cholecystitis

Dong-Feng Chen, Lu Hu, Ping Yi, Wei-Wen Liu, Dian-Chun Fang, Hong Cao

Dong-Feng Chen, Lu Hu, Ping Yi, Wei-Wen Liu, Dian-Chun Fang, Hong Cao, Department of Gastroenterology, Daping Hospital, Third Military Medical University, Chongqing 400042, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 39970039

Correspondence to: Dr. Dong-Feng Chen, Department of Gastroenterology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. dfchen9@hotmail.com

Telephone: +86-23-68757362 Fax: +86-23-68813806

Received: August 1, 2005
Revised: December 1, 2006
Accepted: January 23, 2007
Published online: March 14, 2007

Abstract

AIM: To study whether H pylori locate in the gallbladder mucosa of patients with chronic cholecystitis.

METHODS: Using Warthy-Starry (W-S) silver stain and immunohistochemistry stain with anti-H pylori antibodies, we screened paraffin specimens in 524 cases of cholecystitis. H pylori urease gene A (HPUA) and H pylori urease gene B (HPUB) were analyzed by polymerase chain reaction (PCR) in the fresh tissue specimens from 81 cases of cholecystitis.

RESULTS: H pylori-like bacteria were found in 13.55% of the gallbladders of the cholecystitis patients using W-S stain. Meanwhile, bacteria positive for H pylori antibodies were also found in 7.1% of the gallbladders of patients with cholecystitis by immunohistochemistry. Of 81 gallbladders, 11 were positive for both HPUA and HPUB, 4 were positive for HPUA only and 7 were positive for HPUB only.

CONCLUSION: H pylori exist in the gallbladders of patients with chronic cholecystitis.

Keywords: H pylori; Gallbladder mucosa; Chronic cholecystitis; Polymerase chain reaction; H pylori urease gene