Choi WJ, Shin JW, Son JY, Seo DS, Park HS, Han SH, Sung HJ, Cho JH, Cho CK, Yoo HS, Lee YW, Son CG. Toxicological study of the hepatotherapeutic herbal formula, Chunggan extract, in beagle dogs. World J Gastroenterol 2006; 12(46): 7497-7502 [PMID: 17167840 DOI: 10.3748/wjg.v12.i46.7497]
Corresponding Author of This Article
Dr. Son CG, East-West Cancer Center, Dunsan Oriental Hospital of Oriental medical Collage of Daejeon University; 1136 Dunsan-dong, Seo-gu, Daejeon 302-122, South Korea. ckson@dju.ac.kr
Article-Type of This Article
Basic Research
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World J Gastroenterol. Dec 14, 2006; 12(46): 7497-7502 Published online Dec 14, 2006. doi: 10.3748/wjg.v12.i46.7497
Toxicological study of the hepatotherapeutic herbal formula, Chunggan extract, in beagle dogs
Woo-Jin Choi, Jang-Woo Shin, Jin-Young Son, Dong-Seok Seo, Hark-Soo Park, Seung-Hyun Han, Ha-Jung Sung, Jung-Hyo Cho, Chong-Kwan Cho, Hwa-Seung Yoo, Yeon-Weol Lee, Chang-Gue Son
Woo-Jin Choi, Jang-Woo Shin, Jin-Young Son, Jung-Hyo Cho, Chong-Kwan Cho, Hwa-Seung Yoo, Yeon-Weol Lee, Chang-Gue Son, East-West Cancer Center, Dunsan Oriental Hospital of Oriental medical Collage of Daejeon University; 1136 Dunsan-dong, Seo-gu, Daejeon 302-122, South Korea
Dong-Seok Seo, Hark-Soo Park, Ha-Jung Sung, Safety Assessment Center, Korea Testing and Research Institute for Chemical Industry, 7-6, Gomak-ri, Wolgot-myeon, Gimpo-si, Kyonggi-do, Korea
Seung-Hyun Han, Department of Oromaxillofacial Infection & Immunity and Dental Research Institute, School of Dentistry, Seoul National University, 28 Yongon-Dong, Chongno-Gu, Seoul 110-749, South Korea
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Son CG, East-West Cancer Center, Dunsan Oriental Hospital of Oriental medical Collage of Daejeon University; 1136 Dunsan-dong, Seo-gu, Daejeon 302-122, South Korea. ckson@dju.ac.kr
Telephone: +82-42-4709481 Fax: +82-42-4709005
Received: September 19, 2006 Revised: October 25, 2006 Accepted: September 3, 2006 Published online: December 14, 2006
Abstract
AIM: To evaluate the pharmaceutical safety of a Chinese herbal formula, Chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study.
METHODS: Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommended drug dosages in an acute and a subacute toxicological study, respectively. Adverse effects were examined by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, haematology, urinalysis, and biochemical analysis.
RESULTS: In the acute study no change in the body weight, diarrhoea, apetite, mortality rate and histopathology of major organs was observed in male or female dogs with a single administration of CGX at 5 g/kg. No drug-induced abnormalities at analysis of histopathology, haematology, urinalysis, and biochemistry were found with any dose of this drug.
CONCLUSION: CGX is supposed to be very safe when used in a clinical application with a wide therapeutic index.
