Fu KI, Sano Y, Kato S, Saito H, Ochiai A, Fujimori T, Saito Y, Matsuda T, Fujii T, Yoshida S. Primary signet-ring cell carcinoma of the colon at early stage: A case report and a review of the literature. World J Gastroenterol 2006; 12(21): 3446-3449 [PMID: 16733868 DOI: 10.3748/wjg.v12.i21.3446]
Corresponding Author of This Article
Kuang-I Fu, MD, Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobaysashi, Mibu, Shimotuga, Tochigi 321-0293, Japan. fukuangi@hotmail.com
Article-Type of This Article
Case Report
Open-Access Policy of This Article
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Kuang-I Fu, Yasushi Sano, Shigeharu Kato, Hiroki Saito, Takahiro Fujii, Shigeaki Yoshida, Division of Gastrointestinal Oncology and Digestive Endoscopy, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan
Kuang-I Fu, Takahiro Fujimori, Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobaysashi, Mibu, Shimotuga, Tochigi 321-0293, Japan
Atsushi Ochiai, Division of Pathology, National Cancer Center East Research Institute, Chiba 277-8577, Japan
Yutaka Saito, Takahisa Matsuda, Division of Endoscopy, National Cancer Center Hospital, Tsukiji, Tokyo 104-0045, Japan
Correspondence to: Kuang-I Fu, MD, Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobaysashi, Mibu, Shimotuga, Tochigi 321-0293, Japan. fukuangi@hotmail.com
Telephone: +81-282-872130 Fax: +81-282-865678
Received: November 9, 2005 Revised: November 28, 2005 Accepted: December 6, 2005 Published online: June 7, 2006
Abstract
A 67-year-old man, who had undergone surgery to resect multiple gastric cancers 4 years ago, visited our hospital for surveillance colonoscopy. Colonoscopy revealed a discolored, 7-mm in diameter, flat-elevated lesion with central depression in the transverse colon near the splenic flexure. Although the findings of endoscopy and barium enema were suggestive of submucosal invasion, the patient chose to undergo endoscopic mucosal resection. Pathological examination of the resected specimen revealed signet-ring cell carcinoma and a positive surgical margin. A second operation was performed, and no residual tumor or metastasis to lymph nodes was found in the resected specimens. Primary colorectal cancers composed of signet-ring cell carcinoma detected and treated at an early stage are extremely rare. We present a case and review the literature.
