Nakayama T, Yoshizaki A, Naito S, Wen CY, Alipov G, Yakata Y, Sekine I. Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas. World J Gastroenterol 2006; 12(11): 1743-1746 [PMID: 16586544 DOI: 10.3748/wjg.v12.i11.1743]
Corresponding Author of This Article
Toshiyuki Nakayama, MD, Department of Molecular Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. toshi-n@net.nagasaki-u.ac.jp
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Rapid Communication
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World J Gastroenterol. Mar 21, 2006; 12(11): 1743-1746 Published online Mar 21, 2006. doi: 10.3748/wjg.v12.i11.1743
Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas
Toshiyuki Nakayama, Ayumi Yoshizaki, Shinji Naito, Chun Yang Wen, Gabit Alipov, Yuichi Yakata, Ichiro Sekine
Toshiyuki Nakayama, Ayumi Yoshizaki, Chun Yang Wen, Yuichi Yakata, Ichiro Sekine, Department of Molecular Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
Shinji Naito, Division of Pathology, Research Laboratory, National Ureshino Medical Center, Saga 843-0301, Japan
Chun Yang Wen, Department of Digestive Disease, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province, China
Gabit Alipov, Tissue and Histopathology Section, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
Correspondence to: Toshiyuki Nakayama, MD, Department of Molecular Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. toshi-n@net.nagasaki-u.ac.jp
Telephone: +81-95-8497107 Fax: +81-95-8497108
Received: October 11, 2005 Revised: October 25, 2005 Accepted: November 10, 2005 Published online: March 21, 2006
Abstract
AIM: Gastrointestinal stromal tumors (GISTs) are rare. GISTs differ from other mesenchymal tumors of the gastrointestinal tract (e.g. leiomyomas and schwannomas). The purpose of this study was to investigate the role of Ets-1 in the growth and differentiation of GISTs.
METHODS: Twenty-eight GISTs, nine leiomyomas and six schwannomas were examined by immunohistochemical staining method for Ets-1 in this study. Specimens were selected from surgical pathology archival tissues at Nagasaki University Hospital.
RESULTS: Ets-1 protein was expressed in the cytoplasm of cells in all of these tumors. Immunohistochemical staining revealed that 27 GISTs (96.4 %), six leiomyomas (66.7 %), and five schwannomas (83.3 %) were positive for Ets-1. Ets-1 expression was statistically different between GISTs and leiomyomas (P < 0.005). However, there was no correlation between Ets-1 expression and clinical risk categories.
CONCLUSION: Ets-1 plays an important role in the growth and differentiation of GISTs, leiomyomas and schwannomas.
