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World J Gastroenterol. Mar 21, 2006; 12(11): 1681-1685
Published online Mar 21, 2006. doi: 10.3748/wjg.v12.i11.1681
Published online Mar 21, 2006. doi: 10.3748/wjg.v12.i11.1681
Interleukin-10 and chronic liver disease
Li-Juan Zhang, Xiao-Zhong Wang, Department of Gastro-enterology, Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China
Supported by Natural Science Foundation of Fujian Province, No. c0410025
Correspondence to: Xiao-Zhong Wang, Department of Gastroenterology, Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China. drwangxz@pub6.fz.fj.cn
Telephone: +86-591-83357896-8482
Received: October 9, 2005
Revised: October 26, 2005
Accepted: November 10, 2005
Published online: March 21, 2006
Revised: October 26, 2005
Accepted: November 10, 2005
Published online: March 21, 2006
Abstract
Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell populations. Numerous investigations suggest that IL-10 plays a major role in chronic liver diseases. IL-10 gene polymorphisms are possibly associated with liver disease susceptibility or severity. Recombinant human IL-10 has been produced and is currently tested in clinical trials. These trials may give new insights into the immunobiology of IL-10 and suggest that the IL-10/IL-10 receptor system may become a new therapeutic target.
Keywords: Interleukin (IL)-10; Cytokine; Chronic liver diseases; Polymorphisms