Brief Reports
Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2005; 11(32): 5029-5031
Published online Aug 28, 2005. doi: 10.3748/wjg.v11.i32.5029
Effect of Helicobacter pylori infection on gastric mucosal pathologic change and level of nitric oxide and nitric oxide synthase
Yong-Fu Wang, Chun-Lin Guo, Li-Zhen Zhao, Guo-An Yang, Peng Chen, Hong-Kun Wang
Yong-Fu Wang, Chun-Lin Guo, Li-Zhen Zhao, Peng Chen, Hong-Kun Wang, Guo -An Yang, First Hospital, Baotou Medical College, University of Science and Technology of Inner Mongolia, Baotou 014010, Inner Mongolia, China
Author contributions: All authors contributed equally to the work.
Supported by the Science and Technology Committee of Baotou, China, No. 2000-26
Correspondence to: Dr. Yong-Fu Wang, Baotou Medical College, University of Science and Technology of Inner Mongolia, Baotou 014010, Inner Mongolia, China. wyf5168@hotmail.com
Telephone: +86-472-2178195 Fax: +86-472-2129235
Received: October 9, 2004
Revised: December 18, 2004
Accepted: December 21, 2004
Published online: August 28, 2005
Abstract

AIM: To investigate the level of nitric oxide (NO) and nitrous oxide synthase (NOS) enzyme and its effect on gastric mucosal pathologic change in patients infected with Helicobacter pylori (H pylori ), and to study the pathogenic mechanism of H pylori.

METHODS: The mucosal tissues of gastric antrum were taken by endoscopy, then their pathology, H pylori and anti-CagA-IgG were determined. Fifty H pylori positive cases and 35 H pylori negative cases were randomly chosen. Serum level of NO and NOS was detected.

RESULTS: One hundred and seven cases (71.33%) were anti-CagA-IgG positive in 150 H pylori positive cases. The positive rate was higher especially in those with pre-neoplastic diseases, such as atrophy, intestinal metaplasia and dysplasia. The level of NO and NOS in positive group was higher than that in negative group, and apparently lower in active gastritis than in pre-neoplastic diseases such as atrophy, intestinal metaplasia and dysplasia.

CONCLUSION: H pylori is closely related with chronic gastric diseases, and type I H pylori may be the real factor for H pylori-related gastric diseases. Infection with H pylori can induce elevation of NOS, which produces NO.

Keywords: Helicobacter pylori; Nitric oxide; Nitric oxide synthase; Gastric mucosa; Pathology