Expression and significance of heat shock protein 70 and glucose-regulated protein 94 in human esophageal carcinoma

doi:10.3748/wjg.v11.i3.429

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2005; 11(3): 429-432
Published online Jan 21, 2005. doi: 10.3748/wjg.v11.i3.429

Expression and significance of heat shock protein 70 and glucose-regulated protein 94 in human esophageal carcinoma

Xiao-Ping Wang, Guo-Zhen Liu, Ai-Li Song, Rui-Fen Chen, Hai-Yan Li, Yu Liu

Xiao-Ping Wang, Rui-Fen Chen, Guo-Zhen Liu, Ai-Li Song, Hai-Yan Li, Yu Liu, Department of Pathology, Capital University of Medical Sciences, Beijing 100054, China

Author contributions: All authors contributed equally to the work.

Supported by the Youth Research Scientific Foundation of Beijing (02-31)

Correspondence to: Dr. Xiao-Ping Wang, Department of Pathology, Capital University of Medical Sciences, Beijing 100054, China. wxpphd@yahoo.com.cn

Telephone: +86-10-63051455

Received: April 10, 2004
Revised: April 17, 2004
Accepted: May 9, 2004
Published online: January 21, 2005

Abstract

AIM: To investigate the expression and significance of heat shock protein 70 (HSP70) and glucose-regulated protein 94 (grp94) in human esophageal carcinoma and adjacent normal tissues.

METHODS: The expression of HSP70 and grp94 in 78 human esophageal cancer and adjacent normal tissues was studied by immunohistochemistry and pathology photograph analysis.

RESULTS: Both esophageal cancer and adjacent normal tissues could express HSP70 and grp94. Of the 78 cases of esophageal carcinoma, 95.0%(72/78) showed positive HSP70, mainly stained in nuclei, while grp94 was mainly stained in cell plasma, and the positive rate was 71.8%(56/78).There was a significant difference in the expression of HSP70 and grp94 between esophageal cancer and adjacent normal tissues (P<0.01). Compared with adjacent normal tissues, there was a significant difference between differential types and HSP70 expression (P<0.01).

CONCLUSION: HSP70 and grp94 express differently in cell plasma and nuclei. The expression intensity of HSP70 is related to the differentiation of esophageal carcinoma.

Keywords: Esophageal carcinoma, Heat shock protein 70, Glucose-regulated protein 94