Wang LB, Zheng S, Zhang SZ, Peng JP, Ye F, Fang SC, Wu JM. Expression of ST13 in colorectal cancer and adjacent normal tissues. World J Gastroenterol 2005; 11(3): 336-339 [PMID: 15637739 DOI: 10.3748/wjg.v11.i3.336]
Corresponding Author of This Article
Dr. Lin-Bo Wang, Department of Surgical Oncology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, Zhejiang Province, China. wanglinbo@medmail.com.cn
Article-Type of This Article
Colorectal Cancer
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World J Gastroenterol. Jan 21, 2005; 11(3): 336-339 Published online Jan 21, 2005. doi: 10.3748/wjg.v11.i3.336
Expression of ST13 in colorectal cancer and adjacent normal tissues
Lin-Bo Wang, Shu Zheng, Su-Zhan Zhang, Jia-Ping Peng, Feng Ye, Shi-Chang Fang, Jin-Min Wu
Lin-Bo Wang, Jin-Min Wu, Department of Surgical Oncology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Shu Zheng, Su-Zhan Zhang, Jia-Ping Peng, Feng Ye, Shi-Chang Fang, Department of Surgical Oncology, No.2 Hospital, Medical College, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Shu Zheng, Department of Surgical Oncology, No.2 Hospital, Medical College, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No.39770818
Correspondence to: Dr. Lin-Bo Wang, Department of Surgical Oncology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, Zhejiang Province, China. wanglinbo@medmail.com.cn
Telephone: +86-571-86090073 Fax: +86-571-86090073
Received: December 12, 2003 Revised: December 18, 2003 Accepted: January 8, 2004 Published online: January 21, 2005
Abstract
AIM: To investigate the in situ expression of suppression of tumorigenecity 13 (ST13) mRNA in both colorectal cancer and adjacent normal tissues.
METHODS: Colorectal cancer cell lines SW1116, SW620 and CoLo205 were enrolled to confirm the feasibility of the in situ hybridization procedure. Seven colorectal cancer and adjacent normal tissues were included for RNA-RNA in situ hybridization.
RESULTS: The expression of ST13 in the seven normal colon tissues was positive and the positive signals appeared in mucosal cells. Only three of the seven colorectal cancer tissues had positive hybridization signals that appeared in adenocarcinoma cells.
CONCLUSION: The expression of ST13 decreases in colorectal cancer tissue compared with that in adjacent normal tissue. ST13 is mostly expressed in colorectal epithelia and adenocarcinoma cells.
