Relationship between metabolic enzyme polymorphism and colorectal cancer

doi:10.3748/wjg.v11.i3.331

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 11, Issue 3

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3688)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-3) series.

Item

Count

PDF

313

HTML

2930

Figures (1-2)

221

Tables (1-3)

224

Sum=3688

Jan 21, 2005 (publication date) through Dec 21, 2024

Times Cited of This Article

Times Cited (57)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Jan 21, 2005; 11(3): 331-335
Published online Jan 21, 2005. doi: 10.3748/wjg.v11.i3.331

Relationship between metabolic enzyme polymorphism and colorectal cancer

Kun Chen, Qin-Ting Jiang, Han-Qing He

Kun Chen, Qin-Ting Jiang, Han-Qing He, Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 30170828

Correspondence to: Professor Kun Chen, Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China. ck@zju.edu.cn

Telephone: +86-571-87217190 Fax: +86-571-87217184

Received: February 14, 2004
Revised: February 18, 2004
Accepted: March 4, 2004
Published online: January 21, 2005

Abstract

AIM: To clarify the influence of genetic polymorphisms on colorectal cancer.

METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data.

RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)-rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYP1A1 L1e462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05).

CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype.

Keywords: Colorectal cancer; Glutathione S-transferase T1; N-acetyltransferase; Polymorphism