Mild hypothermia protects liver against ischemia and reperfusion injury

doi:10.3748/wjg.v11.i19.3005

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 21, 2005; 11(19): 3005-3007
Published online May 21, 2005. doi: 10.3748/wjg.v11.i19.3005

Mild hypothermia protects liver against ischemia and reperfusion injury

Cheng-You Wang, Yong Ni, Yan Liu, Zhi-Heng Huang, Min-Jie Zhang, Yong-Qiang Zhan, Hai-Bin Gao

Cheng-You Wang, Yong Ni, Yan Liu, Zhi-Heng Huang, Min-Jie Zhang, Yong-Qiang Zhan, Hai-Bin Gao, Department of Hepatobiliary Surgery, Shenzhen Second People’s Hospital, Shenzhen 518035, Guangdong Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Cheng-You Wang, Department of Hepato-biliary Surgery, Shenzhen Second People’s Hospital, Shenzhen 518029, Guangdong Province, China. chengyouw@163.com

Telephone: +86-755-26106138 Fax: +86-755-83356952

Received: October 9, 2002
Revised: October 10, 2002
Accepted: November 13, 2002
Published online: May 21, 2005

Abstract

AIM: To determine whether mild hypothermia could protect liver against ischemia and reperfusion injury in pigs.

METHODS: Twenty-four healthy pigs were randomly divided into normothermia, mild hypothermia and normal control groups. The experimental procedure consisted of temporary interruption of blood flow to total hepatic lobe for different lengths of time and subsequent reperfusion. Hepatic tissue oxygen pressure (P_tiO₂) and aspartate aminotransferase (AST) values were evaluated, and ultrastructural analysis was carried out for all samples.

RESULTS: Serum AST was significantly lower, and hepatic P_tiO₂ values were significantly higher in the mild hypothermia group than in the normothermia group during liver ischemia-reperfusion periods (P = 0.032, P = 0.028). Meanwhile, the histopathologic injury of liver induced by ischemia-reperfusion was significantly improved in the mild hypothermia group, compared with that in the normothermia group.

CONCLUSION: Mild hypothermia can protect the liver from ischemia-reperfusion injury in pigs.

Keywords: Ischemia-reperfusion injury, Hypothermia, Liver, Pathophysiology