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©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 1, 2004; 10(15): 2303-2304
Published online Aug 1, 2004. doi: 10.3748/wjg.v10.i15.2303
Published online Aug 1, 2004. doi: 10.3748/wjg.v10.i15.2303
Alverine citrate induced acute hepatitis
Mehmet Arhan, Seyfettin Köklü, Aydln S Köksal, Ömer F Yolcu, Senem Koruk, Irfan Koruk, Ertugrul Kayaçetin, Kavaklik mah, Ahmet Apaydln cad, Sultan Apartment, No 39/7, Sahinbey 27060, Gaziantep, Turkey
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Irfan Koruk, Kavaklik mah, Ahmet Apaydln cad, Sultan Apartment, No 39/7, Sahinbey 27060, Gaziantep, Turkey. irfan_koruk@yahoo.com
Telephone: +90-342-3397615 Fax: +90-312-3124120
Received: February 20, 2004
Revised: March 3, 2004
Accepted: March 13, 2004
Published online: August 1, 2004
Revised: March 3, 2004
Accepted: March 13, 2004
Published online: August 1, 2004
Abstract
Alverine citrate is a commonly used smooth muscle relaxant agent. A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent. A 34-year-old woman was investigated because of the finding of elevated liver function tests on biochemical screening. Other etiologies of hepatitis were appropriately ruled out and elevated enzymes were ascribed to alverine citrate treatment. Although alverine citrate hepatotoxicity was related to an immune mechanism in the first case, several features such as absence of predictable dose-dependent toxicity of alverine citrate in a previous study and absence of hypersensitivity manifestations in our patient are suggestive of a metabolic type of idiosyncratic toxicity.
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