Relationship between microvessel density and telomerase activity in hepatocellular carcinoma

doi:10.3748/wjg.v10.i14.2147

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 15, 2004; 10(14): 2147-2149
Published online Jul 15, 2004. doi: 10.3748/wjg.v10.i14.2147

Relationship between microvessel density and telomerase activity in hepatocellular carcinoma

Yun-Feng Piao, Min He, Yang Shi, Tong-Yu Tang

Yun-Feng Piao, Yang Shi, Tong-Yu Tang, Department of Gastroenterology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China

Min He, Comprehensive Department of Infection, Changchun Infectious Hospital, Changchun 130021, Jinlin Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Yang Shi, Department of Gastroenterology, First Hospital of Jilin University, No.1 Xinmin Road, Changchun 130021, Jilin Province, China. shiyangwhy@163.com

Telephone: +86-431-5612242 Fax: +86-431-5612542

Received: February 21, 2004
Revised: March 4, 2004
Accepted: March 12, 2004
Published online: July 15, 2004

Abstract

AIM: To study the relationship between microvessel density (MVD), telomerase activity and biological characteristics in hepatocellular carcinoma (HCC).

METHODS: S-P immunohistochemical method and telomeric repeat amplification protocol (TRAP) were respectively used to analyze the MVD and telomerase activity in 58 HCC and adjacent normal tissues.

RESULTS: The MVD in HCC with metastasis, lower differentiation or without intact capsule was significantly higher than that in HCC with intact capsule, higher differentiation, or without metastasis. While MVD had no relationship with tumor size, hepatic virus infection and other clinical factors. Telomerase activity was related to differentiation degree, but not to tumor size or histological grade. MVD in HCC with telomerase activity was higher than that in HCC without telomerase activity.

CONCLUSION: MVD and telomerase activity may serve as diagnostic criteria of HCC in earlier stage. Meanwhile, there may be a cooperative effect between MVD and telomerase on the growth and metastasis of HCC.

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