Curative effects of interferon-&alpha; and HLA-DRB1 -DQA1 and -DQB1 alleles in chronic viral hepatitis B

doi:10.3748/wjg.v10.i14.2116

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 15, 2004; 10(14): 2116-2118
Published online Jul 15, 2004. doi: 10.3748/wjg.v10.i14.2116

Curative effects of interferon-α and HLA-DRB1 -DQA1 and -DQB1 alleles in chronic viral hepatitis B

Guo-Qing Zang, Min Xi, Ming-Liang Feng, Yun Ji, Yong-Sheng Yu, Zheng-Hao Tang

Guo-Qing Zang, Min Xi, Yong-Sheng Yu, Zheng-Hao Tang, Department of Infectious Diseases, 6th People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China

Ming-Liang Feng, Yun Ji, Shanghai Blood Center, Shanghai 200051, China

Author contributions: All authors contributed equally to the work.

Supported by the Foundation of Shanghai Municipal Health Bureau, No. 01444

Correspondence to: Dr. Guo-Qing Zang, Department of Infectious Diseases, 6th People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China

Telephone: +86-21-64369181

Received: November 26, 2003
Revised: January 13, 2004
Accepted: February 1, 2004
Published online: July 15, 2004

Abstract

AIM: To investigate the association between curative effects of interferon-α and partial human leucocyte antigen (HLA) II alleles in chronic viral hepatitis B.

METHODS: Sixty patients with chronic viral hepatitis B in Shanghai were treated with a standard course of treatment with interferon-α for 6 mo. HLA-DRB1, -DQA1, and -DQB1 alleles were detected by polymerase chain reaction-sequence specific primer (PCR-SSP) method.

RESULTS: Frequencies of HLA-DRB1*04 (P < 0.025) and HLA-DQA1*0303 (P < 0.01) in non-responders were significantly higher than those in partial and complete responders. Frequencies of HLA-DQA1*0505 (P < 0.025) and HLA-DQB1*0301 (P < 0.005) in partial and complete responders were significantly higher than those in non-responders.

CONCLUSION: Non-response to interferon-α therapy is positively correlated with HLA-DRB1*04 and HLA-DQA1*0303, and negatively correlated with HLA-DQA1*0505 and -DQB1*0301 in patient with chronic viral hepatitis B. HLA II genes of the identification alleles provide a method for evaluating outcome of interferon-α treatment.

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