Brief Reports
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 15, 2004; 10(10): 1537-1539
Published online May 15, 2004. doi: 10.3748/wjg.v10.i10.1537
Effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation
Chao Zhang, Zhan-Kui Liu, Pei-Wu Yu
Chao Zhang, Zhan-Kui Liu, Pei-Wu Yu, Department of General Surgery, Southwest Hospital, Third Military Medical University, Gaotan Yan, Chongqing 400038, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Professor, Dr. Chao Zhang, M.D., Department of General Surgery, Southwest Hospital, Third Military Medical University, Gaotan Yan, Chongqing 400038, China. meizhang6688@yahoo.com
Telephone: +86-23-68773074
Received: June 6, 2003
Revised: September 15, 2003
Accepted: October 22, 2003
Published online: May 15, 2004
Abstract

AIM: To investigate the effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation.

METHODS: Concenration of bile acid and total bacterial counts (TBC) in gastric juice were measured in 49 patients with peptic ulcer before and after gastrectomy. One year after the operation, sample of gastric mucosa taken from all the patients were used for histological examination.

RESULTS: The concentration of gastric bile acid was significantly increased in group B-I, or B-II and SV + A than that in group HSV (P < 0.05-0.01). The abnormal histological changes in the remnant gastric mucosa were more common in the first 2 groups than in the last group.

CONCLUSION: The type of gastrtectomy can affect bile reflux. The abnormal histological changes in the remnant gastric mucosa are closely related to the elevation of bile acid concentration and increase of TBC in gastric juice. HSV can effectively prevent bile reflux and keep the gastric physiological functions stable.

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