Dysregulated cortical synaptic plasticity under methyl-CpG binding protein 2 deficiency and its implication in motor impairments

Figure 1 Graphic illustration for methyl-CpG binding protein 2-mediated pathway of neuronal gene transcription. The activity of methyl-CpG binding protein 2 (MeCP2) is mediated by phosphorylation, which can response to cell cycle or cellular activity. MeCP2 exerts pluripotent functions at genetic and epigenetic layers, including directly or indirectly affecting gene transcription, or modifying chromatin structures. Such modulatory network eventually affects both structure and function of neurons[17-20,23,26].