Brain reward circuitry: The overlapping neurobiology of trauma and substance use disorders

Figure 2 Conditioned fear in cocaine use. The dorsal and ventral subdivisions of medial prefrontal cortex are shown at the center, with their respective outputs to the amygdala controlling fear shown at right, and those to the nucleus accumbens, controlling cocaine, seeking shown at left. Green depicts pathways that activate fear and cocaine seeking. Red depicts pathways that inhibit fear and cocaine seeking[65]. Citation: Peters J, Kalivas PW, Quirk GJ. Extinction circuits for fear and addiction overlap in prefrontal cortex. Learn Mem 2009; 16(5): 279-288. Copyright ©Cold Spring Harbor Laboratory Press 2009. Published by Cold Spring Harbor Laboratory Press[65].