Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy

Figure 1 Cellular localization of polyamine-metabolizing enzymes and antizyme inhibitor 2 in human and rat brain with nickel-enhanced streptavidin-biotin immunocytochemistry. A: Ornithine decarboxylase immunoreactive neurons of the human prefrontal cortex. Bar = 70 µm; B: Antizyme inhibitor 2 expressing neurons in the human prefrontal cortex. Bar = 30 µm; C: Antizyme inhibitor 2 immunoreactive fiber in the human temporal cortex. Note the typical pearlchain-like structure as already described by others[18]. Bar = 20 µm; D: Strong spermine oxidase immunoreactive neurons in the human hypothalamus (interstitial nucleus). Bar = 30 µm; E: Multiple spermine oxidase expressing neurons in the CA2 region of the human hippocampus. Bar = 30 µm; F: Spermine oxidase expressing neurons in rat medial prefrontal cortex. Bar = 55 µm; G: Low power microphotograph of agmatinase immunoreactivity in human habenula. Bar = 140 µm; H: Single agmatinase immunopositive neuron in the human insular cortex. Bar = 30 µm.